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Low Dose Naltrexone and Neuropathy

Posted by lorirenee1 @lorirenee1, Jan 6, 2020

Hi everyone. Lori Renee here. I have been on Low Dose Naltrexone for about 2 weeks. It may be too soon to post about this medication, but I thought I would post now, and post again, in about 2-4 weeks. Bottom line is that Low Dose Naltrexone has helped considerably with my foot neuropathy. My pain is sometime gone, and usually only reaches a level 5 or so, sometimes. Usually, it is about a 2-3, kind on a low level foot throbbing. Enough to be annoying, but not enough to want to cut my feet off. Without it, I wanted to cut my feet off. Certain problems do remain, so my feet are far from normal still. I put on shoes, and feel like my socks are bunched up, or that there are pebbles in them. It takes me a long time to find a shoe to wear. The balls of my feet still feet like they have been stuck in cement, but not all the time. My toes still feel stuck together, or too widely spread. All crazy sensations of neuropathy. So Low Dose Naltrexone has not taken all the crazies away. However, the pain is so much lower, that I am amazed. I have only used Kratom once in two weeks, which is remarkable. I have no side effects at all from the drug. It is not covered by my Medicare insurance, but is about 35 bucks a month. Not too bad. Anyway, it really is the best pain killer I have tried, other than Kratom. I don't have to taste the vile Kratom, so that is very good. I suggest that everyone give it a try. I read that it helps approximately 25% to 40% of people that try it. The endorphin rush it produces is loaded with pain fighters. Yes, give it a try. I will post again about it, as I use it more. Love to all, Lori Renee

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jeffrapp | @jeffrapp | Jan 7, 2020

Hi Lori Renee
Where do you get the LDN from? I understand it comes in 50 mg tablets, and the dose is 4.5 mg per day.
Thanks
Jeff

REPLY
1 reply
lorirenee1 | @lorirenee1 | Jan 7, 2020
In reply to @jeffrapp "Hi Lori Renee Where do you get the LDN from? I understand it comes in 50..." + (show)
@jeffrapp

Hi Lori Renee
Where do you get the LDN from? I understand it comes in 50 mg tablets, and the dose is 4.5 mg per day.
Thanks
Jeff

Jump to this post

@jeffrapp Hi Jeff, The 50 mg pill is the regular Naltrexone. It is not the Low Dose Naltrexone. That is not the right pill. You must find a pharmacy that will make this Low Dose Naltrexone, 4.5 mg. pill for you. Furthermore, you generally start out at about 3.0 mg., and have to work up to 4.5 mg. after 3 days. It is called a "compounding pharmacy" that you have to find. The pharmacist, literally, makes the LDN special order, just for you. You cannot just cut up the 50 mg. regular Naltrexone pills. You will not get the dosage right. Good luck, and give it a try. Lori

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2 replies
lorirenee1 | @lorirenee1 | Jan 7, 2020
In reply to @rwinney "Hey there. Thank you for the info. Yes ma'am I have LDN in my cabinet as..." + (show)
@rwinney

Hey there. Thank you for the info. Yes ma'am I have LDN in my cabinet as we speak and will try it soon. My only obstacle is getting through pain at night without hydro. I was hoping extra strength THC would do the trick but it's generally not. Last night I caved after hour and half in bed miserable and took hydro. (I use heat packs all day and sleep with them too, which is best relief, fyi). So that I would not be able to do with out wasting the 1 LDN pill for that day. My PM Dr says if not noticing a positive change after 3 mo then LDN is not right for you. Keep going girl and I'm so happy to hear you are having positive results! 😁

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@rwinney I have pain at nite also. Not severe, but not good. I have a few inhales of marijuana. Very light inhales. I hate being stoned. That and the LDN seem to do the trick for the evening. I do not remember; do you use marijuana? It does seem to be ok at night in terms of not feeling too much pain. If the LDN worked for you, it might be even enough. You never know. To clarify, you are saying that the night LDN dose you would take, would interfere with the Hydro from working? The LDN would close the receptor sights, and the hydro could no longer attach to them. I am sleepy. I hope I am making sense. Have marijuana in me as I write. I hope I am making some sense!!!!! Lori

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1 reply
Mentor
Rachel, Volunteer Mentor | @rwinney | Jan 7, 2020
In reply to @lorirenee1 "@rwinney I have pain at nite also. Not severe, but not good. I have a few..." + (show)
@lorirenee1

@rwinney I have pain at nite also. Not severe, but not good. I have a few inhales of marijuana. Very light inhales. I hate being stoned. That and the LDN seem to do the trick for the evening. I do not remember; do you use marijuana? It does seem to be ok at night in terms of not feeling too much pain. If the LDN worked for you, it might be even enough. You never know. To clarify, you are saying that the night LDN dose you would take, would interfere with the Hydro from working? The LDN would close the receptor sights, and the hydro could no longer attach to them. I am sleepy. I hope I am making sense. Have marijuana in me as I write. I hope I am making some sense!!!!! Lori

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Correct. Need that 6 hour seperation.

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terrydclaar | @terrydclaar | Jan 8, 2020
In reply to @lorirenee1 "@terrydclaar check your private messages here. I wrote you a private message. Lori Renee" + (show)
@lorirenee1

@terrydclaar check your private messages here. I wrote you a private message. Lori Renee

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Not sure how to access private messages. Can you help me, thanks, Terry

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1 reply
jeffrapp | @jeffrapp | Jan 8, 2020
In reply to @lorirenee1 "@jeffrapp Hi Jeff, The 50 mg pill is the regular Naltrexone. It is not the Low..." + (show)
@lorirenee1

@jeffrapp Hi Jeff, The 50 mg pill is the regular Naltrexone. It is not the Low Dose Naltrexone. That is not the right pill. You must find a pharmacy that will make this Low Dose Naltrexone, 4.5 mg. pill for you. Furthermore, you generally start out at about 3.0 mg., and have to work up to 4.5 mg. after 3 days. It is called a "compounding pharmacy" that you have to find. The pharmacist, literally, makes the LDN special order, just for you. You cannot just cut up the 50 mg. regular Naltrexone pills. You will not get the dosage right. Good luck, and give it a try. Lori

Jump to this post

Thanks

REPLY
Mentor
John, Volunteer Mentor | @johnbishop | Jan 8, 2020
In reply to @terrydclaar "Not sure how to access private messages. Can you help me, thanks, Terry" + (show)
@terrydclaar

Not sure how to access private messages. Can you help me, thanks, Terry

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@terrydclaar click the small envelope at the top of the screen next to your profile icon.
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1 reply
terrydclaar | @terrydclaar | Jan 9, 2020
In reply to @johnbishop "@terrydclaar click the small envelope at the top of the screen next to your profile icon." + (show)
@johnbishop

@terrydclaar click the small envelope at the top of the screen next to your profile icon.

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Thanks for your help, John.

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Mentor
Rachel, Volunteer Mentor | @rwinney | Jan 14, 2020

I found this informative write up on LDN. It clarifies alot in simple language.
https://www.amymyersmd.com/2017/05/low-dose-naltrexone/

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offthegrid | @offthegrid | Jun 12, 2020

I take the 50mg pill crush it and add 50ml of distilled water (letting it sit for an hour then shake before use) to it then draw up the dosage with a measured food/child's med syringe and add that to juice. 1ml = 1mg etc. I refrigerate it. There are lots of people doing this and plenty of how to videos on YT.

The one time cost was about $40 to buy the things needed to do this right and my copay for 90 50mg naltrexone tablets is $10. That's a 1,000 day supply of ldn or more depending on your optimal dose but the use by date is only good for a year so realistically its a 365 day supply which would be for me $240 at the compounding pharmacy.

This way it's easy to change the dose to get what's right for you. A lot cheaper than going through a compound pharmacy. All they do is crush a larger naltrexone pill and fill gel caps with a lower amount maybe add filler. I looked at going to a local compounding pharmacy and it was $60 for 90 days. Honestly it wasn't the cost so much as having the flexibility to change the dose starting low and moving higher then down again if that's what works.

There is another version of naltrexone called dextro-naltrexone that is being researched and that does not block opioid receptors so larger doses would be possible.

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