Hi @thefam2016 and welcome to Connect. That must be so frightening to experience your Mom's brother pass away and have worrisome test results involving the same area of concern in your mother.

@harper7745 and @tigreyes2004 both have experienced with elevated amylase or lipase (or both) and may be able to offer support as you look for answers and may be able to share further testing options.

@marvinjsturing has experience with pancreatic cancer and may be able to share his experience.

Have you thought about getting a second opinion on her CT? Sometimes it helps to get a second opinion. How long has your Mom's fatigue, weight loss and, nausea, vomiting and night sweats been occurring?