@bill54321 When I had myoclonic jerks it was when I was passing out during a painful nerve conduction test and my stress level was pretty high. It makes me wonder if it is part of a fight or flight response. That's just a hunch; I don't have data to support it. The doctor sent me to a sleep study and I did kick my leg as I was falling asleep. Sometimes I wake myself up doing that and it seems to be when I'm half asleep half awake. I do have twitches from time to time when I'm awake, but don't think about it. I think stress causes more of it. Twitches can also happen from pressure on nerves and we all develop patterns in our fascia of the way we move and rest. A physical issue like that can be treated with myofascial release which is a form of stretching and physical therapy. The fascia is a big net that can get stuck and everything held in it can get stuck and stop moving properly and it can compress a muscle or nerve. When I am stressed, my body reacts, and muscles and fascia tighten up. My physical therapist helps and I do a lot of stretching on my own. My other thought could be something like a magnesium deficiency which is common. Magnesium helps muscles relax and is needed for detox pathways in the body. We do have a discussion on Myofacial Release. I don't know if it will help, but it is something to try and your body can learn to relax doing this. https://connect.mayoclinic.org/discussion/myofascial-release-therapy-mfr-for-treating-compression-and-pain/