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DiscussionQuestions about Hormone Blockers: Side Effects?
Breast Cancer | Last Active: Aug 6, 2020 | Replies (27)Comment receiving replies
Replies to "@kathysway, I changed the title of your discussion to be specific to your question. @sparklegram is..."
Hi Colleen,
Thank-you so much for the links, especially for the Hormonal Therapy Side Effects Comparison Chart. I’m about to start taking an Aromatase Inhibitor. My oncologist said I could choose any of the three. But with all the serious side effects, and to make that decision, I’m looking for randomized controlled trials (RCT) that answer these questions:
1. Are there links to RCT trials that demonstrate the efficacy of these drugs > Arimidex (anastrozole) vs. Aromasin (exemestane) vs. Femara (letrozole) vs. a control group of women who do not take an AI? It would be ideal to see any more recent reports that reevaluated the efficacy and where more years of data were included.
2. My oncologist indicated the standard AI dosage is exactly the same for every woman regardless of stage/grade/type of estrogen positive breast cancer. Are there any RCT studies available where the dosage was evaluated based on the severity of the cancer? Did the trials dosage determination include that criteria too?
3. The oncologist also noted the standard dosage is the same if the woman weighs 90 or 395+ pounds. Are there any RCT studies available where the dosage was evaluated based on the patients weight or BMI?
I’ve looked for this info on many websites including the FDA, NIH, Mayo clinic and more without luck and truly appreciate any info you may provide.