My husband age 64 diagnosed last April 2018 with Waldenstrom with bone marrow biopsy, his main complaint was fatigue and did have a few episodes of numbing and tingling in fingertips occasionally, then in October he had an episode of severe headaches that were treated for a sphenoid sinus infection the edema was so bad along with headeaches they did an MRI/MRA of head which was normal, then they suspected Temporal Arteritis which they then did a bilateral biopsy that came back inconclusive, he was on a high dose of prednisone 60mg and has just weaned off as of March 1, he is still fatigued and now battling a URI, his Oncologist/Hematologist suggest treatment when his IGM level is 3,000 and his is 1600 now. He is frustrated with the not knowing and feeling so fatigued most days, he was always very active cycling, going to the gym etc.