Anyone Heard of Pirenzepine for Small Fiber Neuropathy?

For humans (from the google patent doc), pirenzepine is typically dosed up to no more than 300mg a day.

In the rat studies, they were giving 10mg/kg orally which seems like a lot for a human to ingest. The person in the reddit link I posted was using only 25mg a day.

In their phase 2 studies, they're testing different topical preparations. In the study I read, it's up to 75mg applied topically.

An interesting part of all of this is that it was discovered accidentally. There are several drugs in this class and at least a few regrow peripheral nerves. Oxybutin is used to control overactive bladder and is given transdermally. A physician reported that one of his patients had reversed her neuropathy symptoms after being on it. (https://search.proquest.com/openview/981503a69793ba0ca6338bc10bfa98c6/1?pq-origsite=gscholar&cbl=1896353)

Is there a way to self trial 4% pirenzepine applied topically? Could i buy it from the japan manufacter in fill form and make a cream?

Sure. The cream isn't sold but you can make the pills into a topical med.

I'm new to this neuropathy blogsite. Did you ever find a source for pirenzepine in Japan and have you been able to order and use
the drug for your neuropathy and did it help? Please reply.
pmogen

@bruceleelives, have you looked at the website Neurotalk.org? There is an interesting discussion regarding perenzipene also oxybutynin which had proved helpful for neuropathy pain. Helen

Hi @bruceleelives, I assume you are familiar with the company Winsantor and their current phase 2 trial for WST-057 (and perhaps phase 3 by now)? I have read that it is legal to buy pirenzepine in Japan but have not heard of anyone here on Connect trying that. If you manage to get any and try to use it I would definitely be interested to know your results. Best and good luck, Hank

Hello pmogen and a big welcome to the group! I haven't heard of pirenzepine but am interested to know how it works for you if you are able to get ahold of it. I use 4% Lidocaine solution (might be over the counter) on my knees where for some reason, I feel the most burn. I apply it with a Q-Tip. I use 5% Lidocaine patches for my back which are prescribed snd very expensive!. These two are the best I have used. I wish you all the best. Warm regards, Sunnyflower

Winsantor and the FDA are making their topical Pirenzepine cream available for early access. You’ll need to work with your physician to get it, but the FDA approves 99% of these requests.
https://mailchi.mp/winsantor.com/the-neurotransmission-update-expanded-access-covid-19-disruption-and-clinical-trials-updates?e=98a8a0ab42

Interesting ... a medicine that reverses the dying process of a human organ like the nervous system could have many more applications ... I will ask my Neurologist/Pain Specialist about Pirenzipine. Peggy

Winsantor's site has an explanation of how it works. Pretty interesting stuff. Two other drugs also in phase 2 trials that do a similar thing.