@bruceleelives, have you looked at the website Neurotalk.org? There is an interesting discussion regarding perenzipene also oxybutynin which had proved helpful for neuropathy pain. Helen

Hi @bruceleelives, I assume you are familiar with the company Winsantor and their current phase 2 trial for WST-057 (and perhaps phase 3 by now)? I have read that it is legal to buy pirenzepine in Japan but have not heard of anyone here on Connect trying that. If you manage to get any and try to use it I would definitely be interested to know your results. Best and good luck, Hank

Hello pmogen and a big welcome to the group! I haven't heard of pirenzepine but am interested to know how it works for you if you are able to get ahold of it. I use 4% Lidocaine solution (might be over the counter) on my knees where for some reason, I feel the most burn. I apply it with a Q-Tip. I use 5% Lidocaine patches for my back which are prescribed snd very expensive!. These two are the best I have used. I wish you all the best. Warm regards, Sunnyflower

Winsantor and the FDA are making their topical Pirenzepine cream available for early access. You’ll need to work with your physician to get it, but the FDA approves 99% of these requests.