Anyone Heard of Pirenzepine for Small Fiber Neuropathy?

Posted by cwallen9 @cwallen9, Mon, Jan 28 9:19am

I just read articles about a drug called Pirenzepine that is being studied to help heal nerve damage. It is being touted as a cure for small fiber neuropathy. I think it is still in the study phase, but is used for other things such as stomach ulcers.

@cwallen9 I had not heard of pirenzepine used for small fiber neuropathy but I did find some research information.

Aug 1, 2018 – Pirenzepine and MT7 also prevented peripheral neuropathy induced by the chemotherapeutic agents dichloroacetate and paclitaxel or HIV …
Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy (PDF)
https://www.researchgate.net/publication/312478000_Selective_antagonism_of_muscarinic_receptors_is_neuroprotective_in_peripheral_neuropathy

Practical Pain Management – Anti-Muscarinic Drugs May Reverse Peripheral Neuropathy January 30, 2017
https://www.practicalpainmanagement.com/resources/news-and-research/anti-muscarinic-drugs-may-reverse-peripheral-neuropathy

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Hi, @cwallen9 – thanks for pointing out that this drug is being studied for use with small fiber neuropathy. Perhaps other members who've talked about this condition may be familiar, like @elsa @rgolia13 @clairecas @fbell330 @djroberts, and have further information or thoughts to share?

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@lisalucier

Hi, @cwallen9 – thanks for pointing out that this drug is being studied for use with small fiber neuropathy. Perhaps other members who've talked about this condition may be familiar, like @elsa @rgolia13 @clairecas @fbell330 @djroberts, and have further information or thoughts to share?

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I have heard about the use for small fiber neuropathy for that medicine but when I ask my neurologist nobody seems to know anything about it. Maybe this will help get people talking about it.

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As far as I know, it is not being used yet for neuropathy. I talked to my neurologist about it, and he was not aware of it. I have read about it also, but it is just being studied now for neuropathy.

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I just heard from Dr. Kim a few days ago. Second Phase clinical trials will start later this year including for chemo caused neuropathy. The company is called WinSanTor. Their product is WST-057.

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@cbcbasket

I just heard from Dr. Kim a few days ago. Second Phase clinical trials will start later this year including for chemo caused neuropathy. The company is called WinSanTor. Their product is WST-057.

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Hi @cbcbasket, welcome to Connect. @navid80, @jordanabrams30, and @ericvnelson have discussed Winsantor in posts in another discussion here on Connect: https://connect.mayoclinic.org/discussion/its-just-been-two-weeks-could-this-be-small-fiber-neuropathy/?pg=1#comment-274842

Here is the link to the Winsantor website – https://winsantor.com/

Are you trying to participate in the clinic trial?

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@johnbishop

Hi @cbcbasket, welcome to Connect. @navid80, @jordanabrams30, and @ericvnelson have discussed Winsantor in posts in another discussion here on Connect: https://connect.mayoclinic.org/discussion/its-just-been-two-weeks-could-this-be-small-fiber-neuropathy/?pg=1#comment-274842

Here is the link to the Winsantor website – https://winsantor.com/

Are you trying to participate in the clinic trial?

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Thanks, and yes I would like to participate. I already registered with WinSanTor and contact them periodically.

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@cbcbasket @johnbishop Winsantor appears to be doing great things and I think a lot of us hold out hope that they have truly found a cure. They are also trying to do a crowdsourcing for funding which I have considered to invest in to ensure they progress!

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@jordanabrams30

@cbcbasket @johnbishop Winsantor appears to be doing great things and I think a lot of us hold out hope that they have truly found a cure. They are also trying to do a crowdsourcing for funding which I have considered to invest in to ensure they progress!

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It does sound promising but I noticed a tiny little disclaimer under WinSanTor's Solution heading on their site — …(Please keep in mind that although this drug is believed to work for multiple indications of PN, the mechanism below is specific to treating DPN). I'm assuming they are talking about diabetic peripheral neuropathy and may not help with other neuropathies.

Here's a research article from the American Diabetes Association that lists some WinSanTor investors/researchers:

Muscarinic Receptor Antagonist Improves Nerve Fiber Function in Subjects with Type 2 Diabetes and Peripheral Neuropathy
http://diabetes.diabetesjournals.org/content/67/Supplement_1/58-OR.abstract

Still, it sounds hopeful.

Liked by happytobehere

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@johnbishop

It does sound promising but I noticed a tiny little disclaimer under WinSanTor's Solution heading on their site — …(Please keep in mind that although this drug is believed to work for multiple indications of PN, the mechanism below is specific to treating DPN). I'm assuming they are talking about diabetic peripheral neuropathy and may not help with other neuropathies.

Here's a research article from the American Diabetes Association that lists some WinSanTor investors/researchers:

Muscarinic Receptor Antagonist Improves Nerve Fiber Function in Subjects with Type 2 Diabetes and Peripheral Neuropathy
http://diabetes.diabetesjournals.org/content/67/Supplement_1/58-OR.abstract

Still, it sounds hopeful.

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Actually, they are including chemo induced neuropathy, per my communications with them. My fear is that even if it works for some it may not help me because mine is possibly dual induced and has been here for about four years, i.e. permanent.

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@cbcbasket

Actually, they are including chemo induced neuropathy, per my communications with them. My fear is that even if it works for some it may not help me because mine is possibly dual induced and has been here for about four years, i.e. permanent.

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That would be one of my concerns also since I've had idiopathic small fiber peripheral neuropathy for 20+ years.

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@johnbishop

That would be one of my concerns also since I've had idiopathic small fiber peripheral neuropathy for 20+ years.

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Really great points. One of the things Mr Kim mentioned to me was while the focus is on DPN and CPN the science appears to show the mitochondrial make up of most neuropathies appear to be similar. Now the only concern I have is outside elements that caused the neuropathy in the first place will they allow recovery. For example if you have autoimmune which is what it appears I have isn’t addressed will it allow for recovery or will it continue to attack? Just something to consider one thing that is of interest to me would be for them to look at a pill solution to become system wide and not so specific to skin soluble; potentially addressing autonomic nerves etc. At the end of the day it appears someone is making great inroads to something no one else has been able to in the past.

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I wish they would hurry up so we could try it!

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@sadfeet

I wish they would hurry up so we could try it!

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Me to because I play the guitar and love writing songs but now my fingers are going very numb. I pray all this is true.

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@jordanabrams30

Really great points. One of the things Mr Kim mentioned to me was while the focus is on DPN and CPN the science appears to show the mitochondrial make up of most neuropathies appear to be similar. Now the only concern I have is outside elements that caused the neuropathy in the first place will they allow recovery. For example if you have autoimmune which is what it appears I have isn’t addressed will it allow for recovery or will it continue to attack? Just something to consider one thing that is of interest to me would be for them to look at a pill solution to become system wide and not so specific to skin soluble; potentially addressing autonomic nerves etc. At the end of the day it appears someone is making great inroads to something no one else has been able to in the past.

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Just to say that pirenzepine (PZ) in pill form already exists. I’m in the U.K. and here it is used for hypersalivation (drooling) caused by other medications. Apparently it used to be used for stomach ulcers. It would be worth looking to see if it is available in the US. The scientists at WinSanTor, specifically Paul Fernyhough is conducting preclinical studies to see if PZ induces outgrowth in autonomic nerves.

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