@ca426 I was told to take them either with or without food, but to be consistent. An online check of how to take these medications confirms that if you take them without food more is absorbed, taking them with food causes less to go into your bloodstream. So yes, you can do either, but you need to be consistent to keep the level of immunosuppressant in your system. As I said too, I was able to go from 4 mg to 2.5 when I started taking them without food. I consider that to be a rather large change. For me, the goal is to take as little medication as possible, so taking a smaller dose is appealing, over the convenience of taking them with my breakfast.

The following article explains this:
Effect of time of meal consumption on bioavailability of a single oral 5 mg tacrolimus dose.
https://www.ncbi.nlm.nih.gov/pubmed/11269569
JK

I never heard this until this year about being consistent in taking meds with or without food. I was on drugs when they told me before being released post transplant so I guess that part was a little fuzzy. Glad to know now so I can take the best possible care of myself. Anyone else wish we could retake those classes to see if we missed anything on the first go-round?