I will nudge my medicine time by intervals before my trip if it is in another time zone so that is works out to be on my regular time of day sequence. (8AM; 8PM). I discussed this with my transplant dept. and it works for me. But one time I nudged it in the wrong direction! Boy was that ever a mess to figure out - won't do that again!
Of course, I have to readjust when I return home.

FYI - I just returned home from our annual trip and when we collected our "Hold" mail, there was a Prograf kit waiting for me!

Happy and Safe Travels to all!