Thanks for posting about your husband's nausea problem, @maxaz1. From what I understand proteins are what keeps the Sinemet from being assimilated by the brain.. Has your husband considered taking the Sinemet with carbs, not protein (like yogurt, milk, etc). Perhaps a bread product or crackers would work better.

Has he been checked for other GI problems? If not, that might be a good idea as well.

Here is some information about Sinemet and food from the Michael J. Fox website, https://www.michaeljfox.org/understanding-parkinsons/living-with-pd/topic.php?nutrition which both you and @susan62 might find helpful.

Here is the first paragraph from that article:

"SHOULD YOU AVOID ANY FOODS OR SUPPLEMENTS WITH PARKINSON'S DISEASE?
The medication levodopa (Sinemet) is a protein building block so it competes for absorption with other proteins. Eating a very proteinic meal reduces the likelihood of effectively absorbing levodopa, so you may want to leave meat, fish and cheese for dinner and eat more carbohydrates and vegetables during the day. Taking medication on an empty stomach -- 30 minutes before or 60 minutes after a meal -- allows the drug to reach the small intestine and absorb faster. However, a carbohydrate snack (crackers, toast, oatmeal) with the medication may be necessary to prevent nausea."

As you can see from this article, Sinemet only needs to be taken 30 minutes before a meal and a carbohydrate snack can be taken with the med in order to avoid nausea, just avoid protein foods.

Will you post again and let us know how your husband is doing?

Hi Maxine. I can totally sympathize with your husband. I often feel nauseated too. I certainly don’t feel like eating. The thought or scent of food makes me want to wretch. I eat not for enjoyment, but because I have to.
Teresa has given me a few things to try, which I am in the process of doing. One thing I do that seems to help a bit is to drink a little diet Ginger Ale right after I take the Sinemet. Just a thought.