I was on 40mg over 10 years ago for UC. In the interim I developed severe stage 3 COPD. Knowing prednisone isn't really good for anyone especially long term I weaned myself down to 15mg daily about 6 years ago. It's about as far as I could go without impacting my breathing. Guess my lungs got use to it and like it. I have had uncontrolled diabetes for over 6 years (i'm sure prednisone related) went from 185 -220, faces is puffer than normal, swollen feet, swollen abdomen (prednisone , diabetes, & little to no exercise) for the most part I sleep good. I think I'm going to take another shot at getting of prednisone at least for a while to see if I can lose weight and get my sugar down.8 years ago I would never take an aspirin unless I absolutely needed it and now take 10 pills in the morning and 7 at night, Plus 3 inhalers. I'd like to get back to my fighting weight if only for a few months 🙂 Taking a lower dose does help my breathing and when I experience a flare up we do a micro boost (40 for 3 days , 30 for 3days , 20 for 3 days then back to normal) in addition and antibiotic. So far it's kept me out of the hospital.