Hello, @sqnomore - welcome to Mayo Clinic Connect. I trust that being a part of this large thread on getting off Quetiapine (Seroquel) will be helpful. If you click VIEW & REPLY, in the email notification, you can scroll back through the past and recent posts. Sounds like @kwilder01 may have the challenge of sleep during a Quetiapine (Seroquel) taper in common with you, and @derryman @jakedduck1 @mxyzptlk and @mrsminniemouse may also have some feedback on dealing with sleep loss from the taper and how to maintain sleep quality.

Are you having trouble falling asleep, @sqnomore, or mainly just awakening much earlier than you'd like?

I'm in the same situation as you. I was on 600mg at night (prescribed by a psychiatrist who mistook peri menopause, an unhappy marriage and fatigue caused by undiagnosed psoriatic arthritis for bipolar 2). 10 yea rs later, I'm out of the marriage, out the other side of menopause and my inflammation is under control. Problem is the drugs she prescribed have been so hard to shake. I'm now weeks clear of 60mg duloxetine (Cymbalta) after months of weaning down the dose to virtually nothing. Still getting weird spiciness, nausea, emotional sensitivity (which is probably just my personality coming back). Now down to 75mg of seroquel, thanks to a handy pill cutter and will go down to 50mg later this week. I'm learning how to sleep again. without being bombed out of my mind When I dropped from 200 to 100mg sleep was a big issue, so did it on holidays when I was relaxed. I'm trying to do calming things before bed, like reading, and writing down anything that is on my mind well before bed.

I used to get a racing heart, with it beating out of my chest an hour after my night dose of seroquel, which was too high a dose for me. Because it wasn't working (i.e. I was still unhappy in the marriage and still exhausted - the dr kept upping the dose). I sometimes fainted if I had to go to the toilet. I'd also eat the entire fridge and developed a binge eating disorder. I am hoping that being moderate and exercising non obsessively will help shift the weight sustainably.