Thanks. I am new to this and definitely want to see the amin discussion so you may point me in the right direction anytime. The main changes are that either the Hydrea is not working as it use to OR he fact that I have had leg pain for about 6 mos. Originally, we thought it was sciatic problems and my PC doctor sent me to Physical Rehab for 2 months. The Physical Therapists told me I should go back to my doctor and see what else was going on. So, I was sent to a pain specialist. Limited results and for a very short time. He referred me to an orthopedic doctor. I have had some steroid shots and my oncologist thinks that is what has driven my platelets back up to a dangerous level. She has not changed y dosage of Hydrea yet but I go back the 14th for more lab work. I have been reading more about ET ad find that my leg pain COULD BE from the ET, possibly morphing into Myelofibrosis. I was walking 2 miles a day months ago and suddenly my legs were just hurting and I was unable to walk long distances. I am on a walker now, and am really frustrated because no one has really been able to tell me why I have leg pain, all the way from hip to toes. I do have MILD arthritis, for which I recieved a steroid shot. Some success. But still a lot of leg pain. I am looking for answers. I do not merely want to cover up the pain, at least not until I find out why I am hurting so much.