Hi Optimust,

Thank you for your reply. I was aware that vitamin B12 is water soluble which is what is so concerning about high numbers. And many of the things I have read suggest that if it is high it is a functional B12 deficit because it means you are not utilizing B12. But I am also not excreting it which also seems like it should be a matter of concern.

I know that sometimes a high Vitamin B12 level is the first sign of something more serious and often appears before other markers do. I looked up Polycythemia Vera and I have many of the symptoms. What I don't have so far is increased red or white blood cells. My platelets went up 30 points at my last blood test but were still within normal range.

May I asked what type of doctor diagnosed your polycythemia vera? Was it a hematologist? I sent my file to UC San Francisco Medical Center Hematology Department because they state on their website that high Vitamin B12 is something that should be thoroughly investigated. I sent it in mid-June and I still have not heard from them. Every time I call to follow up the new patient coordinator tells me that my file is still in review. I know that there are so many people who are worse off than me so I imagine that their files get higher priority, and rightfully so. And so I wait.

Talkdoc