Hi @mattkl817 ....I had a similar experience with my first known EBV infection when I was almost 21 and then a bad relapse 6 months later. I was working as an RN that included 12 hour shifts, often no breaks, and odd hours which I am certain contributed to the relapse. After 3 months off, I could only go back to work part-time and pretty much had to "couch it" on my days off. I know that is no fun for a twenty-something, right!!?? Anyway, I am now 47 and have a greater understanding of my journey with EBV relapses. I relapsed again in my 30s and most recently at age 43. I am now thankful to be on the upswing of my last relapse. I have spent the past few years reading and researching about EBV and chronic fatigue syndrome. Most people can have an EBV infection or even develop mono and go on to live healthy, happy lives. But there are some, like us, who struggle with those life-changing relapses. The theory is that the stress from the initial virus sets the body into a forever stress mode causing a cascade of challenging symptoms for the patients and the doctors. I obviously can't diagnose or advise any treatment for you or have the room in this platform to explain everything in detail, but I can share a few things I've learned....EBV was only part of my illness. It turns out that it was Chronic Fatigue Syndrome which involves many other body systems, not just the immune system. It is not well understood or even recognized by conventional physicians. Even places such as the Mayo Clinic do not have up to date information on their website. Mayo Clinic still indicates cognitive behavioral therapy and graded exercise therapy for CFS which have been disproven to be effective and may even be harmful. The CDC is a better source. Only recently has there been updated information published in medical journals. Be aware that any kind of stressor whether it is lack of sleep, surgery, work stress, relationship stress, another illness -- can set you back. According to the research I've done, there is not one thing (such as a medication or lifestyle) that helped me overcome the debilitating fatigue. It involved hitting it from many angles -- a clean diet, supplements, DNRS (retrainingthebrain.com), proper sleep, and stress management to begin to get well. Dr. Rodger Murphree in Alabama (www.yourfibrodoctor.com) has been a tremendous help along with Annie Hopper's DNRS Program (www.retrainingthebrain.com). You can google both of those people for more info if you'd like. Also, be aware that conventional doctors may not understand EBV and the fatigue you are dealing with. Don't be disheartened by that. Most have NOT been educated about recurring EBV and/or CFS. Many of those suffering however, have had results with a functional medicine or integrative physician. You are your best advocate! Don't give up! Take care of yourself!