Leaky gut?

Hello @nanceedeefeperi -- Welcome to Mayo Connect. I'm glad you found us. Connect is a good place to ask questions and learn what other members with similar health problems are doing for treatment. It looks like you have a lot going on with your health. I'm glad that you are searching for others with similar health concerns. Being your own advocate is important. I'm not sure if you saw that there is a discussion open for "Leaky Gut, Constipation and Gluten Free". Here is a link to the discussion:
https://connect.mayoclinic.org/discussion/leaky-gut-constipation-and-gluten-free/bookmark/?ajax_hook=action&_wpnonce=f403b0d456
@kanaazpereira posted the following information in the discussion that may be helpful for you:

You might be interested in viewing these talks on the Gastroenterology & GI Surgery Page (https://connect.mayoclinic.org/page/gastroenterology-and-gi-surgery/) on Connect:

– The ‘Pros’ of Probiotics: Dr. Joseph Murray on Mayo Clinic Radio https://connect.mayoclinic.org/newsfeed-post/the-pros-of-probiotics-dr-joseph-murray-on-mayo-clinic-radio/
– Is Larazotide Acetate the Answer to Leaky Gut? https://connect.mayoclinic.org/newsfeed-post/is-larazotide-acetate-the-answer-to-leaky-gut-1/

Hoping for a quick recovery for you and release from the ER.

John

The mention of gluten intolerance and an itchy rash make me suspicious of dermatitis herpetiformis which is the skin manifestation of celiac disease. You may want to look into getting a skin biopsy of the rash to see if this could be the culprit. But be sure that your physician understands how to do the biopsy -- have to follow special guidelines of staining and immunoflourescence.

I have been tested for celiac disease and was negative. I’ve been reading about leaky gut and I have a lot of the symptoms. My GI Dr seems to have knowledge of leaky gut, he took a stool sample and blood work. I’ve been to two Drs, Urgent care and the ER. Stopped eating sugar, gluten free with plenty of fruits/vegetables and purified water.

Hi @nanceedeefeperi,

I'm tagging @clemlaa @ambrose @meemer @mieke @michellecrcrn @uneeq1 @lighthouseceliac, who may have more insights to share about the symptoms you're experiencing.

Since you mentioned you are gluten intolerant, I thought you might wish to view this post in which Dr. Joseph Murray talks about people who may not have celiac disease, and cannot tolerate gluten, but experience symptoms similar to those with celiac disease.
– The Strange World of Non-Celiac Gluten Sensitivity https://connect.mayoclinic.org/newsfeed-post/the-strange-world-of-non-celiac-gluten-sensitivity-1/

I think often times the assumption is made that anyone who is suffering with inflammation has leaky gut. Often times tests aren't run to necessarily diagnose the problem -- but rather measures are taken to deal with the problem. A good place to start is with a Whole 30 elimination diet with the autoimmune protocol also.

"Leaky gut" seems to be fairly tropical at the moment. I wonder if the attention is warranted.

Hi @davejscott and welcome to Connect!

You're right. Leaky gut syndrome is hotly debated at this time.

Here are various opinions on leaky gut:

- Is Leaky Gut Syndrome a Real Condition? An Unbiased Look (Healthline) https://www.healthline.com/nutrition/is-leaky-gut-real

- Debunking the Myth of ‘Leaky Gut Syndrome’ (GI Society) https://www.badgut.org/information-centre/a-z-digestive-topics/leaky-gut-syndrome/

- Leaky gut: What is it, and what does it mean for you? (Harvard Medical School) https://www.health.harvard.edu/blog/leaky-gut-what-is-it-and-what-does-it-mean-for-you-2017092212451

Gastroenterology & GI Surgery Page on Connect has some great videos about leaky gut, by Mayo Clinic experts: https://connect.mayoclinic.org/page/gastroenterology-and-gi-surgery/ Like this one by Dr. Murray.

- Is Larazotide Acetate the Answer to Leaky Gut? https://connect.mayoclinic.org/page/gastroenterology-and-gi-surgery/newsfeed/is-larazotide-acetate-the-answer-to-leaky-gut-1/

@davejscott, is this a condition that you or someone you know is experiencing?

Thank you so much for this info. This has been very helpful! I see this OP is from 2018. Is there newer research or information on this topic? Has the debate been settled whether leaky gut is legitimate for patients who do not have celiac disease?

davejscott, intestinal permeability may be a result of a thiamine deficiency. So asking about "Leaky Gut" may have brought you to learning more about this remarkable vitamin that requires magnesium to become bioactive..
https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo
https://nootropicsexpert.com/vitamin-b1-thiamine/

Welcome to Mayo Clinic Connect, @eslavik1. Mayo Clinic has done a recent study with significant findings I thought you would like to read this article.
Understanding the role of proteolytic activity in mediating irritable bowel syndrome symptoms and disruption of intestinal barrier function https://www.mayoclinic.org/medical-professionals/digestive-diseases/news/understanding-the-role-of-proteolytic-activity-in-mediating-irritable-bowel-syndrome-symptoms-and-disruption-of-intestinal-barrier-function/mac-20485226

Have you been given an official diagnosis for anything yet, @eslavik1?