Hi my daughters psychiatrist tried her on every med from A to Z and her reactions were all over the place. After years of trying so many medications from a young age this psychiatrist decided to do with DNA testing on her. It turned out that she has a double MTHFR gene mutations. If you look this up it tells you that people with the MTHFR gene mutation do not metabolize folic and b vitamins properly. Therefore leaving them depleted of what is essential for proper brain function. Having this gene mutation also causes people to not metabolize chemicals properly and this leads to your body not responding correctly to some medications. My daughter's dr. Gave her the Enlyte with delta folate and she did very well with it.