1. < Depression & Anxiety

Anyone have nausea with Trintellix?

Posted by nansmith @nansmith, Nov 1, 2017

Anyone have nausea with Trintellix 5mg? How long did it last? Been taking for almost 6 weeks and still have some nausea...will it get worse if I titrate to 10mg? Thanks.

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heidi1346 | @heidi1346 | Jan 17, 2021
In reply to @lacy2 "..just happened to get notification of your question so don't want to interfere as not on..." + (show)
@lacy2

..just happened to get notification of your question so don't want to interfere as not on it nor been on it, (never heard of it before) but I did just check on Internet and it is listed (diarrhea) as a common side effect, but also says to tell your Doctor if you get this side effect......although I have not taken it I have IBS-D, C.Diff and now fecal incontinence/diarrhea daily and I hope that it does go away for you as it's horrible to live with. I also get it with all antibiotics... and when we are on antibiotics we cannot take anti-diarrhea meds!!! ......so wishing you the best outcome.... J.S.

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Thank you. Did you get cdiff from trintellix

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1 reply
heidi1346 | @heidi1346 | Jan 17, 2021
In reply to @colleenyoung "Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several..." + (show)
@colleenyoung

Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several digestive related issues for you, including nausea, upset stomach and severe diarrhea. Nausea is the most common side effect of this drug. I'd like to bring @rossjt @marjou @trip17 @elwooodsdad @petangelkat1 @jeanmnyc @marazion @alamogal635 and @kelster69 into this discussion so they can share their experiences with you.

While we wait for others to join in the discussion, you may also wish to see this discussion thread:
- Switching to Trintellix or Low Dose Naltrexone (LDN) https://connect.mayoclinic.org/discussion/trintillix/

Heidi, have you discussed the side effects you're experiencing with your doctor? How long have you been taking Trintellix? What dosage?

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I took two duculox the night before so maybe that is why the diarrhea is so bad. 5 mg

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1 reply
Valerie | @lacy2 | Jan 18, 2021
In reply to @heidi1346 "Thank you. Did you get cdiff from trintellix" + (show)
@heidi1346

Thank you. Did you get cdiff from trintellix

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Hello No I got C.Diff from four sulphur antibiotics in 4 months for UTIs and then 2 more from urologist (very nice doctor)..even that antibiotic had a warning about it possibly causing C.Diff and I can send a photo..... but already had IBSD. It wasnt the diarrhea as one might get from a bad meal or such, but was very bad and as I mentioned, the Imodium I took before to semi control it could not be taken while on antibiotic - even when I had to take over 140 Vancomyin antibiotics for the C.Diff... long story short... it was life changing and I can describe it another time: I certainly dont want to discourage any taking medication because diarrhea is a side effect: but right on the information about the drug you are asking about it says to advise your Dr. if you get diarrhea... then you and your Doctor can decide. It's just that I find there is diarrhea and then there is DIARRHEA.... and unless you have been through it as people have, or suffer from it with IBS-D and other bowel issues, it can be a life changer and has stopped me from travelling or even visiting people etc (pre covid). Hopefully you can find a solution and I wish you the very best, as I too suffer from depression and anxiety, J.S.

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Valerie | @lacy2 | Jan 18, 2021
In reply to @heidi1346 "I took two duculox the night before so maybe that is why the diarrhea is so..." + (show)
@heidi1346

I took two duculox the night before so maybe that is why the diarrhea is so bad. 5 mg

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@heidi1346 Heidi... did you take DucolAx ? Yes that's a laxative .. I have taken it before having Colonoscopy! If you only had diarrhea after taking this, then question might be, do you get diarrhea after taking Trintelix not just when taking Ducolax????? Just curious, J.

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1 reply
heidi1346 | @heidi1346 | Jan 18, 2021
In reply to @colleenyoung "Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several..." + (show)
@colleenyoung

Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several digestive related issues for you, including nausea, upset stomach and severe diarrhea. Nausea is the most common side effect of this drug. I'd like to bring @rossjt @marjou @trip17 @elwooodsdad @petangelkat1 @jeanmnyc @marazion @alamogal635 and @kelster69 into this discussion so they can share their experiences with you.

While we wait for others to join in the discussion, you may also wish to see this discussion thread:
- Switching to Trintellix or Low Dose Naltrexone (LDN) https://connect.mayoclinic.org/discussion/trintillix/

Heidi, have you discussed the side effects you're experiencing with your doctor? How long have you been taking Trintellix? What dosage?

Jump to this post

I will be discussing with doctor tomorrow. 5mg for 4 days and like I said I took duculox the night before. Hope do i know when a discussion is in progress

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heidi1346 | @heidi1346 | Jan 18, 2021
In reply to @lacy2 "@heidi1346 Heidi... did you take DucolAx ? Yes that's a laxative .. I have taken it..." + (show)
@lacy2

@heidi1346 Heidi... did you take DucolAx ? Yes that's a laxative .. I have taken it before having Colonoscopy! If you only had diarrhea after taking this, then question might be, do you get diarrhea after taking Trintelix not just when taking Ducolax????? Just curious, J.

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Yes I got severe dishreah after the duculox. Maybe the diarrhea would not have been so bad if I didn't take the duculox

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heidi1346 | @heidi1346 | Jan 18, 2021

Has anyone gained weight on Trintellix

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heidi1346 | @heidi1346 | Jan 18, 2021
In reply to @colleenyoung "Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several..." + (show)
@colleenyoung

Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several digestive related issues for you, including nausea, upset stomach and severe diarrhea. Nausea is the most common side effect of this drug. I'd like to bring @rossjt @marjou @trip17 @elwooodsdad @petangelkat1 @jeanmnyc @marazion @alamogal635 and @kelster69 into this discussion so they can share their experiences with you.

While we wait for others to join in the discussion, you may also wish to see this discussion thread:
- Switching to Trintellix or Low Dose Naltrexone (LDN) https://connect.mayoclinic.org/discussion/trintillix/

Heidi, have you discussed the side effects you're experiencing with your doctor? How long have you been taking Trintellix? What dosage?

Jump to this post

I talk to my doctor tomorrow. I have been on 5 mg for four days. Maybe if I did not take the Ducolox, the diahreah would not have been so bad. Is weight gain a side effect. Hearing different things

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heidi1346 | @heidi1346 | Jan 18, 2021
In reply to @kelster69 "@heidi1346 , I was on Trintillex for about 6 weeks last summer. I did have nausea..." + (show)
@kelster69

@heidi1346 , I was on Trintillex for about 6 weeks last summer. I did have nausea when I started taking it, and my doctor prescribed an anti-nausea I could take with it. That said, I started to tolerate the drug better after a couple of weeks. No diarrhea, but if the Trintillex works for your depression, maybe you could talk to your doctor about taking something to stop your diarrhea. I've learned that if you find something that helps you, it's worth putting up with the side effects (to a reasonable extent). Depression is hell and anything that you can arm yourself with to fight it is worth trying. All the best to you.

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Thank you

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marjou | @marjou | Jan 18, 2021
In reply to @heidi1346 "I am extremely nauscious from trintellix and have an upset stomach. I believe the Nausia goes..." + (show)
@heidi1346

I am extremely nauscious from trintellix and have an upset stomach. I believe the Nausia goes away but does the upset stomach go away

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I have the nausea and upset stomach at 2.5 mg.

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