Link between GCA and myeloproliferative blood disorders?

Posted by maye33 @maye33, 5 days ago

I've had a pmr diagnosis since 3yrs ago & large vessel GCA diagnosis 2 years ago ( now completely treatment / symptom / disease free for the last year )
My older sister recently has an
Essential thrombocythaemia ( ET) diagnosis.

I've read several medical articles that say Giant cell arteritis is known to be associated with a significantly increased statistical risk and co-occurrence of myeloproliferative neoplasms (MPNs)
Notably Essential Thrombocythemia.

" Studies indicate that a prior diagnosis of GCA is linked to a substantially higher relative risk (estimated around 5.9-fold) of developing myeloproliferative neoplasms such as essential thrombocythaemia. "
"Age-related somatic mutations in blood stem cells-such as JAK2 V617F and TET2 mutations-frequently drive both clonal hematopoiesis and MPNs. These mutations promote systemic inflammation via inflammatory cytokines like IL-1ß and IL-6, which are central to GCA pathogenesis"

My questions are therefore:

Should my sister, and I , be informing our relevant specialists of each other’s diagnoses?

Would stem cell testing for mutations be indicated for our family ?

Has anyone else had a family co occurrence of GCA and a myeloproliferative disease?

Much appreciated if my forum friends, and / or the Mayo clinic , could shed some light on my questions?

Interested in more discussions like this? Go to the Polymyalgia Rheumatica (PMR) Support Group.

These are some great medical questions. Very complicated in nature. Wish I could shed some light. I was diagnosed with GCA/PMR in November of 2023. I am in remission now, was treated only with prednisone, no biologic currently at this time take ibuprofen to manage pain. I Do have a genetic blood “clotting” disorder, prothrombin. There is a family history of factor V Leiden/protrombin clotting condition.

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