@bigk2u I just read your post and wanted to know more about the sponginess. I just started on Eliquis in May for 2 blot clots in my Left leg. In late June I noticed some "swelling" on the inner side of my right knee and over about a month it got bigger and now goes from the knee up the inner thigh. I also have it in the same area on my Left leg but the Right is worse (which is weird cause it is the side Without the clots). I started out describing it as swelling, but over time actually started using the word spongey so was amazed you said the same thing. My vascular medicine doc doesn't know what it is, said it feels more like tissue than anything. Just saw my primary and she doesn't know either and said to go back to vascular. I started looking things up and was wondering if I had lipedema now so am going to ask when I see her in November. BUT based on your comment, maybe it is a side effect of the Eliquis. Just seems really odd that we are both describing the same thing just on different parts of the leg. I am going to try to search Eliquis and I might call the company. I will let you know if I find anything else out. I do the elevation, swim for exercise and use compression thigh high hose. What is rejuvenate vibrating straps?? The only thing that has temporarily decreased the swelling a bit in the thighs is medical massage facia work. Also just had lymphatic massage and the swelling is a little better- just lasts about a week. I have also had some pain to light touch on the thighs intermittently and at times pain in that area when I walk- do you have any of those symptoms?