Psma addition

Posted by whatthef @whatthef, Sep 15 7:33am

My oncologist communicated a newly fda approved treatment for metastatic prostate cancer called “psma addition” for pc that is not resistant to therapy. Has anyone applied this therapy or has any info on this therapy? Thanks

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for mjp0512 @mjp0512

@whatthef - Yep, that's Pluvicto. PSMAddition was a trial specifically adding Pluvicto to ARPI. The recent FDA approval your Dr is referring to (7/31/26) is for castrate sensitive patients. Pluvicto was already approved for castrate resistant disease.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01092-5/abstract
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/170879-fda-approves-pluvicto-for-psma-positive-metastatic-hormone-sensitive-prostate-cancer-mhspc.html

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As @mjp0512 cited "The PSMAddition trial demonstrated that adding Pluvicto (177Lu-PSMA-617) to standard hormone therapy (ADT plus an ARPI) significantly improves radiographic progression-free survival in patients with PSMA-positive metastatic hormone-sensitive prostate cancer." https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01092-5/abstract

There are several discussions in the group about Pluvicto, for example:
- Anyone on Pluvicto? Looking for a support team https://connect.mayoclinic.org/discussion/anyone-on-pluvicto/
- Can anyone share their experience with Pluvicto?https://connect.mayoclinic.org/discussion/can-anyone-share-their-experience-with-pluvicto/

See all: https://connect.mayoclinic.org/group/prostate-cancer/

@whatthef, did you decide to start Pluvicto (177Lu-PSMA-617)? How are you doing?

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