Somatuline Autogel (lanreotide) 120 mg. Where, How and after.
Dear NETs Community,
Hello everyone,
I would like to share my experience and some confusion regarding my first three doses of Somatuline over the past three months.
I received two injections in the UAE and my third injection today, September 18, 2026, in Turkey. What has confused me is that I have received different opinions and different injection techniques in each country.
In the UAE, the injections were given in the upper part of my buttock. After each injection, I could feel a small lump or depot under the skin, which remained noticeable for several weeks. In fact, I can still feel a small lump from a previous injection even after two months.
Today in Turkey, I noticed they usually administer the injection in the abdomen or the upper arm/shoulder area, similar to some vaccines. Because of my previous experience, I asked the healthcare staff to use the same approach as in the UAE and inject it in the upper buttock area. However, the injection was given higher up, closer to my waist. It was also administered much faster than my previous injections. I only felt a brief stinging sensation, and unlike before, I do not feel any lump or depot under the skin.
As a result, I am feeling confused and unsure about which technique is considered correct, or whether these different experiences are all normal. Has anyone else had similar experiences with Somatuline injections? Where is your injection usually given, and do you typically feel a lump under the skin afterward?
I would really appreciate hearing about your experiences so that we can all learn from each other.
Thank you very much.
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I've had about 40 of these injections. Using cold spray immediately before an upper buttock area slowly is the way to go. I always tell the nurse I like it cold and slow.
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2 Reactions@jlsgt thank you for your kind reply, it was helpful, but can you please let me know if you have a lump under the skin each time you take the medicine?
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1 ReactionI’ve had 66 of these injections I rarely have a lump. I get them in the upper part of the butt, I receive these from the same nurses that give these everyday so they have a lot of experience. They don’t offer cold spray at this Cancer center. When I get them when I am out of town they are never as good. Remember to take the weight off your leg of the side you are getting it on. Remind the nurse to push it slow. They get better the more you get,
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2 Reactions"let me know if you have a lump" Maybe twice out of those 40. The key is bringing the injection up to room temp and injecting slooowly.
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2 Reactions@kevinmonroemi , thank you so much for your informative reply. I can confirm every nurse has it own technique depends on the facility guidelines as I had received 2 in same facility I had a lump under the skin for those 2 times and the third time in turkey the nurse says they have given you wrong 2 times and then they give it to me upper part almost in my waist line but no lump this time and they give it too fast like 5 seconds.
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1 Reaction@jlsgt in my case usually they inject it cold and slowly , that I could feel the medicine running inside.
But I think major concern that another nurse thinks they are injecting in the muscles not the fatty layer then I have to speak to the doctor about
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1 ReactionI have taken Somatuline Depot injections for a year in two different cancer centers. Included in the box with the syringe and medicine is a flyer detailing instructions on how to administer the medication, how long to thaw, where to administer and at what speed. It is a very viscous liquid and should be delivered slowly over a specified amount of time. Mine is always given in alternating buttocks muscle near the top of the buttock. My buttocks are quite small, so location is limited. I have a couple of nodules from injection sites in the buttock that show up on scans, but no explanation has been given except that the medication was possibly administered too rapidly. I have never used the spray, although it has been available at both cancer centers. Since the medication is ordered in my name, I have asked to see the sheet of directions prior to having it administered.
Hi, I am no longer Somatostatin avid, but had Somatuline Depot injections monthly from 1/24 to 3/26, always from the same place and always in muscle near top of buttocks on left side only because I have a bladder stim implanted on the right. I totally agree with using cold spray and going slow. I had different nurses most times, but methods were similar and all were very conscientious of method. My injections were taken out of the frig an hour prior to my arrival. I do still have 3 lumps on my left side, tho, that show up in my abdominal MRIs.