Rheum wants Kevzara but Methotrexate much cheaper, work as well?

Posted by boomermeg @boomermeg, 5 days ago

Appreciate any input. I'm newly diagnosed 7/31/26. Started at 15mg, had to go to 20mg, then to 25mg for 2 weeks to get all pain and symptoms under control. Saw my Rheumatologist today, 1st follow-up. I tapered to 22.5mg 7 days ago. She's concerned re flares for me because I had to step up twice just to get under control initially. She wants me to start Kevzara to help me taper over time, hopefully without flares. The Kevzara & Methotrexate both require prior authorization to even get covered by my insurance. Kevzara shows 4,000.00+ price without insurance, while Methotrexate shows 200.00+without insurance. It's a no brainer for me as I've had way too much health expenses already this year. Anyone have experience they can relate about Kevzara, any side effects, or Methotrexate and any side effects? Or any other drug that can help bridge the Prednisone tapers? I appreciate any help at all. Thank you all.

Interested in more discussions like this? Go to the Polymyalgia Rheumatica (PMR) Support Group.

Profile picture for boomermeg @boomermeg

@abd
Thank you very much for this information. My Rheumatologist said that Kevzara could leave a "mark" or something, so thanks. Is the name of the most current medication you were told isn't available "Acetemra"? Is it the specialty pharmacy saying it isn't available? My Rheumatologist said you get Kevzara from a "specialty pharmacy" or something. It seems like it can be a problem, especially if you've been taking a "biologic" type drug that can be so helpful and then suddenly can't get it. I'm sorry this has happened to you. It's hard enough having PMR and taking Prednisone, trying to taper without horrible flares, and then having RX issues on top isn't our idea of fun!! Thanks again for your help. I hope you can get the most recent one ASAP. Blessings.

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@boomermeg Yes Kevzara comes from specialty pharmacy….needs constant refrigeration etc. Had not been a problem for me.

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Profile picture for boomermeg @boomermeg

@abd
Thank you very much for this information. My Rheumatologist said that Kevzara could leave a "mark" or something, so thanks. Is the name of the most current medication you were told isn't available "Acetemra"? Is it the specialty pharmacy saying it isn't available? My Rheumatologist said you get Kevzara from a "specialty pharmacy" or something. It seems like it can be a problem, especially if you've been taking a "biologic" type drug that can be so helpful and then suddenly can't get it. I'm sorry this has happened to you. It's hard enough having PMR and taking Prednisone, trying to taper without horrible flares, and then having RX issues on top isn't our idea of fun!! Thanks again for your help. I hope you can get the most recent one ASAP. Blessings.

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@boomermeg Kevzara website is very helpful……best you read it and side effects, rather than totally relying on our word. It is all individual. Yes, I had a couple of injections in my belly that left a “red mark”. Nothing to get excited about, and stopped after a couple of months.

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Profile picture for tweetypie13 @tweetypie13

@boomermeg Yes Kevzara comes from specialty pharmacy….needs constant refrigeration etc. Had not been a problem for me.

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@tweetypie13
Thanks again. Good to know. Blessings.

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Profile picture for tweetypie13 @tweetypie13

@boomermeg Kevzara website is very helpful……best you read it and side effects, rather than totally relying on our word. It is all individual. Yes, I had a couple of injections in my belly that left a “red mark”. Nothing to get excited about, and stopped after a couple of months.

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@tweetypie13
Thanks. That's what I do for EVERYTHING medical, prescription, cancer, etc. It's always behooved me to research everything myself. I've learned so much this year alone. Even blood tests, test results, etc. That's how I figured out I must have PMR. We are our own best advocates. But, each of you here still give so much help, community, care for eachother and of course, information.
Thanks for mentioning to check things out myself.

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Oral metho made me sick. Injected metho also made me sick. Best price for Kevzara thru insurance was $2500/month but considered outside normal drug tiers so annual max doesn’t apply. Could purchase direct for $1800/month but almost $22k/yr still too much.
Now taking Leflunomide which has enabled me to get down to 5 mg pred daily for first time in over 2 yrs. 🤞🏻 (PMR over 12 yrs)

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Good luck whichever way you decide to go. I was diagnosed last November and put on prednisone at 40 mg. Tapered down to 15 mg in April. Rheumatologist added Methotrexate, mainly due to the cost. Within 4 weeks I had breathing problems. To cut this short, I had acute respiratory failure, in a coma, on life support for 10 days and subsequently in ICU, and spent a total of 70 days in the hospital.
I am hesitant to try anything that warns of lung issues now.

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Profile picture for boomermeg @boomermeg

@jeff97 Thank you so much for all this info. I really appreciate it. I don't take any other expensive drugs, so I'll look at what my total drug max for year is. Really can't afford such high costs per year due to my husband's and my ages but probably make too much to qualify for help, but I'll check that as well for Kevzara and Actemra. This PMR support group is so helpful. I've learned so much from each post. Thank you again and Blessings on your journey.

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@boomermeg

I was diagnosed with PMR in March 2026. I responded extremely well to Prednisone, but asked the rheumatologist to taper me off of it after researching and learning about the side effects of long term use of Prednisone.
She started me on Methotrexate (20 mgs) one per week. Fortunately, I have not experienced any major side effects beside being tired the day after I take it.

The PMR symptoms are under control, but I do have some stiffness, but I’m functioning considerably well.

Good luck to you as you navigate this part of your journey.

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Profile picture for abd @abd

Getting insurance to approve coverage and getting the medicine from manufacturers is indeed a problem. Seems these people want doctors to try other medicines. My experience anyway.
With Kevzara, the cost was covered after my annual deductible for that tier of drug.
Check with your doctors office on the cost.
I was on Kevzara but after the second and third had welts at injection site so my Rheumatologist took me off. I do believe it was helping and noticed a difference right away. I have not been on Methotrexate- from word of mouth and reading it seems to have more risks to it.
Right now I have been on another injection every two weeks but now when I reordered was told it wasn’t available.

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@abd
I've only had four doses of kevzara so far. I get a small welt at the injection site that goes away within an hour. I think it has more to do with my injection skills than the kevzara itself.

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Profile picture for rlstonejr @rlstonejr

Oral metho made me sick. Injected metho also made me sick. Best price for Kevzara thru insurance was $2500/month but considered outside normal drug tiers so annual max doesn’t apply. Could purchase direct for $1800/month but almost $22k/yr still too much.
Now taking Leflunomide which has enabled me to get down to 5 mg pred daily for first time in over 2 yrs. 🤞🏻 (PMR over 12 yrs)

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@rlstonejr
Thank you so much for this information. I too can't afford the extremely high monthly price for Kevzara. I'm looking at any and all alternatives. Right now I'm at 22.5mg (from 25mg) so it's still very early, and I'm hoping I can gradually reduce way down without flares, and maybe need something later, but that might be wishful thinking! Thank you for Leflunomide. I'll look into it as well.
So glad to hear you're down to 5mg right now. I pray you can keep going down. Blessings.

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Profile picture for 76ttop @76ttop

Good luck whichever way you decide to go. I was diagnosed last November and put on prednisone at 40 mg. Tapered down to 15 mg in April. Rheumatologist added Methotrexate, mainly due to the cost. Within 4 weeks I had breathing problems. To cut this short, I had acute respiratory failure, in a coma, on life support for 10 days and subsequently in ICU, and spent a total of 70 days in the hospital.
I am hesitant to try anything that warns of lung issues now.

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@76ttop
I'm so sorry to hear what happened to you with Methotrexate. It must have been horrible and incredibly scary. Not to mention the cost to you financially on top of the physical, mental, emotional costs. This is why pharmaceuticals are so scary. Each one of us is different and while some might be fine, others have drastic side effects. I'm very concerned about these same things so I may not do anything other than Prednisone right now. It depends on everything I find out about all possible alternatives.
I pray you're doing well now. Thank you again for sharing your experience. It's important to know just how serious these things can get.
Blessings.

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