Rheum wants Kevzara but Methotrexate much cheaper, work as well?
Appreciate any input. I'm newly diagnosed 7/31/26. Started at 15mg, had to go to 20mg, then to 25mg for 2 weeks to get all pain and symptoms under control. Saw my Rheumatologist today, 1st follow-up. I tapered to 22.5mg 7 days ago. She's concerned re flares for me because I had to step up twice just to get under control initially. She wants me to start Kevzara to help me taper over time, hopefully without flares. The Kevzara & Methotrexate both require prior authorization to even get covered by my insurance. Kevzara shows 4,000.00+ price without insurance, while Methotrexate shows 200.00+without insurance. It's a no brainer for me as I've had way too much health expenses already this year. Anyone have experience they can relate about Kevzara, any side effects, or Methotrexate and any side effects? Or any other drug that can help bridge the Prednisone tapers? I appreciate any help at all. Thank you all.
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@boomermeg Yes Kevzara comes from specialty pharmacy….needs constant refrigeration etc. Had not been a problem for me.
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3 Reactions@boomermeg Kevzara website is very helpful……best you read it and side effects, rather than totally relying on our word. It is all individual. Yes, I had a couple of injections in my belly that left a “red mark”. Nothing to get excited about, and stopped after a couple of months.
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3 Reactions@tweetypie13
Thanks again. Good to know. Blessings.
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1 Reaction@tweetypie13
Thanks. That's what I do for EVERYTHING medical, prescription, cancer, etc. It's always behooved me to research everything myself. I've learned so much this year alone. Even blood tests, test results, etc. That's how I figured out I must have PMR. We are our own best advocates. But, each of you here still give so much help, community, care for eachother and of course, information.
Thanks for mentioning to check things out myself.
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3 ReactionsOral metho made me sick. Injected metho also made me sick. Best price for Kevzara thru insurance was $2500/month but considered outside normal drug tiers so annual max doesn’t apply. Could purchase direct for $1800/month but almost $22k/yr still too much.
Now taking Leflunomide which has enabled me to get down to 5 mg pred daily for first time in over 2 yrs. 🤞🏻 (PMR over 12 yrs)
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3 ReactionsGood luck whichever way you decide to go. I was diagnosed last November and put on prednisone at 40 mg. Tapered down to 15 mg in April. Rheumatologist added Methotrexate, mainly due to the cost. Within 4 weeks I had breathing problems. To cut this short, I had acute respiratory failure, in a coma, on life support for 10 days and subsequently in ICU, and spent a total of 70 days in the hospital.
I am hesitant to try anything that warns of lung issues now.
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5 Reactions@boomermeg
I was diagnosed with PMR in March 2026. I responded extremely well to Prednisone, but asked the rheumatologist to taper me off of it after researching and learning about the side effects of long term use of Prednisone.
She started me on Methotrexate (20 mgs) one per week. Fortunately, I have not experienced any major side effects beside being tired the day after I take it.
The PMR symptoms are under control, but I do have some stiffness, but I’m functioning considerably well.
Good luck to you as you navigate this part of your journey.
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3 Reactions@abd
I've only had four doses of kevzara so far. I get a small welt at the injection site that goes away within an hour. I think it has more to do with my injection skills than the kevzara itself.
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5 Reactions@rlstonejr
Thank you so much for this information. I too can't afford the extremely high monthly price for Kevzara. I'm looking at any and all alternatives. Right now I'm at 22.5mg (from 25mg) so it's still very early, and I'm hoping I can gradually reduce way down without flares, and maybe need something later, but that might be wishful thinking! Thank you for Leflunomide. I'll look into it as well.
So glad to hear you're down to 5mg right now. I pray you can keep going down. Blessings.
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1 Reaction@76ttop
I'm so sorry to hear what happened to you with Methotrexate. It must have been horrible and incredibly scary. Not to mention the cost to you financially on top of the physical, mental, emotional costs. This is why pharmaceuticals are so scary. Each one of us is different and while some might be fine, others have drastic side effects. I'm very concerned about these same things so I may not do anything other than Prednisone right now. It depends on everything I find out about all possible alternatives.
I pray you're doing well now. Thank you again for sharing your experience. It's important to know just how serious these things can get.
Blessings.
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