PSA still .04 after nine months on doublet Orgovyx and Nubeqa.

Posted by ucla2025 @ucla2025, Aug 28 2:06pm

I would appreciate hearing anyone’s thoughts. My husband has been on doublet Orgovyx and Nubequa for a year now. His last three quarterly PSA results have been .04 (“total” PSA) thru Quest lab. Is this good because PSA holding steady, or bad because it’s not going down? Any ideas how our doc might approach this situation?

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Profile picture for brianjarvis @brianjarvis

It depends on what his PSA was prior to starting doublet therapy (ADT + ARPI).

For example - I know a guy whose PSA was 11,700; he’d be thrilled with an ADT-induced PSA of 0.04. In my case, my PSA was only 7.796 and dropped to <0.008 while on ADT alone.

It’s always good when PSA is holding steady or not going up.

What was your husband’s diagnosis (numbers?) going into treatment? What is his testosterone level now? That will define expectations and how your doctor might approach this situation.

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Hi @brianjarvis. His information is in my bio. His testosterone was not checked this time around, I will ask about that at next appointment.

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