Thyroglobulin increased from .6 to 4.2 in two months

I have not had this happen. But the sharp increase in thyroglobulin may (don't panic) indicate some active cells.
Request a neck ultrasound asap. And perhaps a CT SCAN.
take care.

Yes. PTC. CCDC6-RET mutation for me. RAI did not work. I've had 3 surgeries in 3 and a half years. First was thyroidectomy and central neck disection, second a radical right neck disection and a few weeks ago, another central. I had RAI after the first and second surgery. My endocrinologist is scheduling ultrasounds and bloodwork every 3 months. If it returns on the right or central, will most likely do EBRT instead of surgery because of scar tissue/fibrosis making surgery more difficult and neck stiffness. If it goes to the left side, surgery will work best. It's exhausting but I won't let it win. Doctors say this won't be what kills me. Hang in there, things could be worse. Just one day at a time.

@mcro2121, have you had a chance to review the results of your recent test with your oncologist? Did they re-order the test?

Because RAI is not always effective or more than micro cells were left behind....some of us have had chemo & radiation. I did because they could not get all the cancer cells in surgery. I survived the chemoradiation, a year ago age 72. My scans show no active cells. It was tough but many have done it with success. Perhaps it is an option?

The doctor said chemo was not a treatment option for mine. EBRT is my next option.

@tkj68
Just clarifying. I had EBRT 35 sessions. The chemotherapy is used weekly (not daily) to enhance the radiation.

Hi all, sorry for the delay! My endo is concerned and ordered a PET/CT scan, but naturally my insurance denied the pre authorization, so I had to reschedule while my doctor reviews with insurance to get it approved. Hopefully will be able to do the scan this week, I’m quite anxious about it.

I'm sorry you have anxiety as a result of the rise in tumor marker. I have a great deal of experience with this anxiety, and empathize. I have had PDTC with two rare mutations since late 2021, have endured two surgeries, two RAI treaments (the second of which proved I was RAI refractory) and 8 weeks of radiation last summer. I have TG tests every 3 months and what I've learned is that disease present does not necessarily present itself on a PET CT or U/S of the neck until your numbers reach beyond 100. So, for instance, after my first surgery and RAI treatment, my TG hovered between 0.2 and 0.9 for about a year before the number started to rise, sometimes exponentially between tests. My team did all the requisite imaging-- nothing popped up. I was told that for quite a long time, the disease will remain at microscopic stage: remember, a normal TG reading in a person with no cancer or thyroid disease can measure up to 40. That kind of number in thyroid cancer patient, who no longer has a thyroid, is of concern-- but in my case, the second mass was not found until my TG number shot up to 150. Good luck and know that there is a community here to help.

@ruehoudon
Thank you for writing this. Very helpful. Take care.

@ruehoudon this is so helpful, thank you so much for sharing this!