Nxgen whole Bone Matrix

Posted by anfieldarnie1950 @anfieldarnie1950, 19 hours ago

My sister has been recommended this product after breaking her femur.
She’s been on Prolia for more than 5 years her Bone Density tests have been good however hospital X-rays show that both legs (femur) are extremely brittle
This could result in further breaks
Has anyone had these issues with Prolia and also is anyone taking the supplement above Thank you reading this

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gravity3 | @gravity3 | 12 hours ago

Was it a physician who recommended it? Is it the vitamin and mineral company in the UK?
Femur breaks is a very rare side effect . What treatment is being recommended now?

anfieldarnie1950 | @anfieldarnie1950 | 12 hours ago

A friend recommended it, The company is in Australia (we’re based in Aus)
Apparently femur are fairly with Prolia use in fact another lady admitted with a similar injury.
Thanks for replying

anfieldarnie1950 | @anfieldarnie1950 | 12 hours ago

Fairly common

WilWeten | @wilweten | 6 hours ago

This article at: https://theros.org.uk/information-and-support/treatments-and-medicines/rare-side-effects/unusual-thigh-bone-breaks/ published in 2014 has some interesting information. As to the risk of femur breaks after using some bisphosphonates it says at: https://theros.org.uk/information-and-support/treatments-and-medicines/rare-side-effects/unusual-thigh-bone-breaks/

"Atypical thigh bone fractures are rare. We don't know exactly how many people get them because there isn't much information available.

Some research has shown if 1,000 people were taking drug treatments linked to atypical thigh bone fractures, less than 1 person would have an atypical thigh bone fracture. The other 999 out of 1,000 people would not have an atypical thigh bone fracture.

The risk of having an atypical thigh bone fracture is low. If you’ve been offered a drug treatment for osteoporosis, this means your risk of breaking a bone is high enough that your bones would benefit from a drug treatment. For you, the benefits outweigh any possible risks. In other words, your risk of atypical thigh bone fractures is smaller than your risk of breaking a bone if you don’t have treatment."

But this article Bisphosphonate beak without the bisphosphonate: atypical femoral fracture with denosumab at: https://pmc.ncbi.nlm.nih.gov/articles/PMC12161004/ and published in 2025 says:
"Atypical femur fractures (AFFs) are rare but significant complications associated with antiresorptive therapies, including bisphosphonates and denosumab. These fractures are characterised by stress or insufficiency fractures occurring in the subtrochanteric or diaphyseal regions of the femur, often with minimal or no trauma. The global incidence of AFFs ranges from 1.8 to 113 cases per 100 000 person-years, depending on the duration of bisphosphonate exposure." This is just part of the abstract. The whole article is free to read.