Tips on minimizing withdrawal symptoms from Effexor (aka Venlafaxine)?

Posted by richyrich @richyrich, Nov 2, 2016

I have been taking Effexor/Venlafaxine for years and tried to get off it a few times but each time I try to give up the chemical withdrawal symptoms are a horror story and I give up giving up. Anyone got any tips or tried and tested strategies? Thank you

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I am eight months off of this horrible drug and I'm still having waves and windows that are absolutely terrifying. I'm currently just sitting here in bed trembling I wake up every morning in between 3 am and 6 am and sheer terror for no reason. Other times I feel totally fine and I'm at the gym. I have learned I have a protracted withdrawal syndrome that can last months two years. I don't know what to do. Does anyone have any thing that help helped during this time. I've tried to clonidine to calm my nervous system and intermittent use of muscle relaxers at a very very low amount. My doctor says he hasn't seen anyone as sensitive as me in 30 years.

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Profile picture for catbitess @catamite

Actually, I had no good reason to go off it except that I felt 20 years of a drug was surely long enough. I also believed it would be kind of nice to be able to feel something again, to cry. I was beginning to feel heartless as I had little response to almost everything. I also thought maybe the drug was causing me to sleep so much of my life away. Well, now I cannot sleep at all and that's not working either. I am a zombie. The psychiatrist says maybe I should go on BUSPAR now? What is this drug? He says it has no withdrawal effects. I don't know. I am just goiing to see if I can work this out on my own. My regular doctor is very anal. She gave me 15 lorazapams, and said it they didn't last for 3 months I should go back on effexor. These doctors. I'm just not liking any of them.

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@catamite if you take just 1/4 lorazepam at a time, once a day, theyll last! Thats the problem its hard to know if its withdrawal that gives us horrible symptoms or that we need to stay on it. I dont think Drs or Psychs really know....they seem keen to see us restarted on the drug we're trying hard to be rid of! ☹️

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Profile picture for jsn1711 @jsn1711

I am eight months off of this horrible drug and I'm still having waves and windows that are absolutely terrifying. I'm currently just sitting here in bed trembling I wake up every morning in between 3 am and 6 am and sheer terror for no reason. Other times I feel totally fine and I'm at the gym. I have learned I have a protracted withdrawal syndrome that can last months two years. I don't know what to do. Does anyone have any thing that help helped during this time. I've tried to clonidine to calm my nervous system and intermittent use of muscle relaxers at a very very low amount. My doctor says he hasn't seen anyone as sensitive as me in 30 years.

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@jsn1711 I, too, had extreme withdrawal symptoms after two months off venlafaxine. I presumed I decreased too much too soon, and went back on the drug at a reduced dose. I am now tapering more slowly. The Maudsley Deprescribing Guidelines suggests two approaches for "Management of protracted withdrawal syndrome":
"Limited research and clinical experience suggest people do recover spontaneously from protracted withdrawal without specific intervention, albeit over sometimes long periods. So, a conservative approach to management may be reasonable. Patients often require reassurance that they will improve in time. They also need support...if such states are prolonged, as they can sometimes be debilitating.
"The second option is re-instatement of the original medication....However, when there is a longer delay in re-instatement after the onset of withdrawal effects (e.g. months or longer) the response is less certain." (Page 54.)
I have been where you are, in "sheer terror for no reason." That was after two months off the drug, I did not know what was happening (was unfamiliar with the dependency this drug causes), and didn't feel like I could cope, so I opted to return to a reduced dose and taper more slowly. In your case, since you have days that you feel fine, and you are already eight months out, you may be more apt to "recover spontaneously." In my case, mornings were the worst but I found that physical exercise helped more than anything. What if you went to the gym on those days that you didn't feel like it?
I recommend Mark Horowitz's information online and The Maudsley Deprescribing Guidelines for more information. All the best to you.

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Profile picture for nanke99 @nanke99

Hi! I was on Effexor XR for a few years and got off it several years ago. It was a very difficult process, so I fully sympathize. You MUST wean off
VERY SLOWLY. I don't remember what my dosage was at the time (225mg?), but it took me about 9 months. Please do not let that long time scare you, it's worth going slow, that will be your biggest help w/ withdrawal. At the time I had a very difficult time finding any doctor with experience getting people off it.
Luckily I was advised to to find one and luckily I did. It is considered harder to get off than heroine. Not trying to scare you, just want to make sure you go as slow as possible. Mostly, I was moody/angry, had headaches, and some brain "shivers". The brain shivers I already had while on the meds.
I think we went down in 25mg increments over several weeks for each reduction. Keep us posted and good luck! Just give yourself some time and it will be over before you know it!

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@nanke99 i am on 150 mg ventab xl - i have been tapering down the worst experience ever - anxiety pits, depression and hopelessness. I am bridging it with an SSRI voxigain and my doctor has also given me 2 sos per day ti Friday.
I am having to take time off work.
So this is normal right? I
Going to get off it rightb

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Profile picture for njoys @njoys

@jsn1711 I, too, had extreme withdrawal symptoms after two months off venlafaxine. I presumed I decreased too much too soon, and went back on the drug at a reduced dose. I am now tapering more slowly. The Maudsley Deprescribing Guidelines suggests two approaches for "Management of protracted withdrawal syndrome":
"Limited research and clinical experience suggest people do recover spontaneously from protracted withdrawal without specific intervention, albeit over sometimes long periods. So, a conservative approach to management may be reasonable. Patients often require reassurance that they will improve in time. They also need support...if such states are prolonged, as they can sometimes be debilitating.
"The second option is re-instatement of the original medication....However, when there is a longer delay in re-instatement after the onset of withdrawal effects (e.g. months or longer) the response is less certain." (Page 54.)
I have been where you are, in "sheer terror for no reason." That was after two months off the drug, I did not know what was happening (was unfamiliar with the dependency this drug causes), and didn't feel like I could cope, so I opted to return to a reduced dose and taper more slowly. In your case, since you have days that you feel fine, and you are already eight months out, you may be more apt to "recover spontaneously." In my case, mornings were the worst but I found that physical exercise helped more than anything. What if you went to the gym on those days that you didn't feel like it?
I recommend Mark Horowitz's information online and The Maudsley Deprescribing Guidelines for more information. All the best to you.

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@njoys Hi, what was the reduced dose that you returned to? As I mentioned, it’s going on 11 weeks since my last dose of 6.25 mg, which I took every other day for two weeks. My doctor has suggested that I reinstate using the hyperbolic method, either by counting beads or using a liquid formulation. I’m really struggling with ongoing anxiety, feeling overwhelmed, nervous and afraid, exhaustion, sleepiness, adrenaline rushes, irritability, and other symptoms. They also seem to be worse when I wake up.
I take 10 mg of propranolol to help with the symptoms, but it’s not enough. My doctor also prescribed a low dose of Ativan, but I haven’t taken it because it causes drowsiness. I’m really on the fence about reinstating Venlafaxine, but I’m having a hard time getting through the day-to-day symptoms 😞😢

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For years, the most I was on was 75 mg per day (for hot flashes--which did not stop; hot flashes are a possible side-effect of Effexor!). When I realized two months after quitting that I was in severe withdrawal from stopping too much/too soon, I reinstated the drug at 50 mg (tablet). I stabilized relatively quickly. (Could I have reinstated at 37.5? I don't know.) I have been able to switch between extended release (ER) capsules and the twice-a-day tablets without issues. Since dosage decreases of 5 to 10% are not readily available, my independent (not-a-chainstore) pharmacist created a liquid formulation based on information in The Maudsley Deprescribing Guidelines. Using a syringe, it took me a year to get to about 15 mg per day. Then I switched to counting granules inside 37.5 mg capsules. I am now at approximately 9 mg per day (about 1/4 of the 37.5 mg capsule contents).
One caution: Venlafaxine is manufactured by many different companies, and the contents of the capsules vary. I did not like the looks of the contents of my latest Rx, so spoke with the pharmacist and obtained capsules by another manufacturer where the contents are more consistent in appearance. The pharmacist told me to request capsules from this same company when I need my next refill.

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I went off 150mg of Effexor in January. I had NO withdrawal symptoms because I used a Prozac bridge. I gradually switched to Prozac until I was only on Prozac. Then going off of Prozac was very easy. I have no idea why this isn't recommended to everyone going off Effexor? Ridiculous. You do not have to suffer.

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