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Anyone on Alta 3263?
My mom started the Alta 3263 trial in January 2016 after a lesion was found on her liver. The tumor has shrunk and been contained, but her nausea and lethargy has increased. Curious how others are handling it? Thanks
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It is very encouraging that your mom's liver lesion has shrunk and remained controlled on ALTA-3263. That's wonderful to hear.
The increasing nausea and lethargy/fatigue are definitely worth discussing with the trial team. With an investigational drug, I would make sure they know exactly how much these symptoms have changed rather than assuming they are something she simply has to tolerate. The team may be able to adjust supportive medications, look for dehydration or electrolyte problems, or determine whether a dose modification or treatment break is appropriate under the trial protocol.
I would also ask them to check whether something besides the medication could be contributing—such as anemia, dehydration, nutrition, liver function, thyroid problems, infection, or other medications.
Has anyone else currently taking ALTA-3263 experienced increasing nausea or fatigue over time? If so, what has your trial team done that helped?
@mcharlesfrancis thank you for your response! All her symptoms are logged and discussed but generally the response is that the medication is working and everyone is hesitant to modify dosage if it is working, but she can stop it anytime it becomes intolerable. She’s not there yet. She has regular bloodwork to check items you have listed. Results are stable in general, her lethargy is not aligned with test results but she can’t shake it off. CT tomorrow and if all is stable still, will push harder on Dr for suggestions. Thank you, appreciate the support.