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Is it Waldenstrom Macroglobulinemia?

Blood Cancers & Disorders | Last Active: Aug 11 9:14pm | Replies (19)

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Profile picture for marcwall @marcwall

No one could diagnose you from that presentation. You are not providing the Myeloid NGS Panel sequencing, CBC/CMP/Diffential/MAN DIFF, and other testing that "excludes" other possibilities. What was the biopsy block's relevant B-cell "cellularity"? The final classification also requires matching these laboratory flags with serum protein electrophoresis (SPEP/IFE), serum IgM levels (very important), and the "physical appearance of the cells under the microscope" in the bone marrow biopsy core. That last part is important. The hematologist-oncologist would want to speak to the pathologist and get his personal interpretation of the cellular state(s) right after the biopsy results came back. His perceptions would be noted in his personal notes. They are the best interpretation of "what he actually saw the cells look like."

While this limited amount of information is pointing toward WM/LPL, the doctor might start with MGUS until all of other variables are taken into account (and/or excluded). Just my opinion.

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Replies to "No one could diagnose you from that presentation. You are not providing the Myeloid NGS Panel..."

@marcwall No symptoms kow. He's not too forthcoming w his equative analysis and these sensible pts u make may open him up. I'll let u know. Do u have WM or are u an oncologist?

@marcwall just woke up w slight nosebleed w bld on pillow. No other symptoms. Informed my hemotologist/oncologist.