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Started Orgovyx 5 weeks ago & am having adverse symptoms.
After starting Orgovyx 5 weeks ago, I feel a significant decline in my mental health. I had been on Eligard Injection for the previous 10 months (also had 6 weeks of EBRT and have been on Abiraterone for 10 months). Since Orgovyx, there has been a noticeable shift, primarily in depressive episodes. Does it make sense to go back to Eligard or stick with Orgovyx given the reduced cardiovascular impact? I'm still waiting for my oncologist to give me insight (treatment team said stop Orgovyx and oncologist will reply).
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@jeffmarc Jeff, your explanation makes a lot of sense! This is why I love this group. I have a prostate cancer oncologist friend (not my doc) who frequently asks for insight from my perspective. We who are enduring this journey are the real-deal imbedded reporters for the journey. I gratefully appreciate all of you who have share your insights and experiences. Since starting treatment, I have longed for this community.
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1 ReactionHi,
Any idea on how long the other two ADT type drugs stay in your system? I can’t imagine what that must be like with possibly three ADT drugs in your system.
Dave 3+4
@clevelandguy
Lupron has a half-life of 3 hours. Orgovyx Has a half-life of 25 hours.
Neither drug is going to be in the system for a long time, They will both have lowered the testosterone and that is the only common thing.
@jeffmarc According to Google:
“Patients on Lupron for a year or more can expect a much more gradual return of normal energy levels, muscle mass, and hormonal balance. Lupron typically takes anywhere from 1 to 3 months to wear off after a 1-month dose, but it can take 3 to 12+ months after long-acting depot shots or multi-dose treatments”. I have heard like comments from people taking Lupron on various forms.
Dave 3+4
@clevelandguy
This has nothing to do with Lupron however, It is how long it takes for your testosterone to return, that is what gets you all of those physical improvements. It actually takes 3 to six months for a one month shot to wear off and with some nine months to a year for the effects of Lupron lowering testosterone to go away.
If you had a one month Lupron shot, you will have no Lupron left in your body after about 31 days. That’s how the drug is designed.
Orgovyx allows testosterone to come back sooner because it is an Antagonist while Lupron is an agonist. Not because the drug itself remains in the body.
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1 Reaction@jeffmarc
That’s what I said in my previous post Jeff. And how big of dosage you get(mg) makes the shot effects last longer according to Google, makes sense to me. The half life might be what you said but the side effects last much longer than a few days.
Dave 3+4