Y90 AND Captem Combo

Posted by laree @laree, Jun 26, 2025

Pnets KI67 25%. My husband had 3 captems cycles. The last cycle had toxicity and became sick. Anyone experience Y90 procedure for Pnets mets to the liver? I have read many net patients use Captem to shrink tumors for a few cycles. Not sure why the Dr wants to dive into Y90 already. Unless it is because my husband got sick the last cycle of Captem. But didn't use anti nausea meds either, unfortunately. Anyone have good results with Y90 and was successful?

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Profile picture for laree @laree

Has anyone else experienced, Gerd, swallowing problems, asphoguitis after a few months of Captem? Also High glucose, type 2 diabetes from chemo medication. Anyone having good results with Everlomis? Thank you for any thoughts.

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@laree I had all of those issues from the cancer. None can be directly attributed to Captem.

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Profile picture for djchambers @djchambers

@laree
I was on captem. 1st round I had low platelets. 2nd round low white blood count. I also ended up in ER with intense chest pain. I thought it was related to indigestion. It was GERD and esophagitis.
3rd round I had colon spasms so bad I almost fainted. My primary Dr gave me anti-spasm meds and suggested dietary changes. That helped. I also needed fluids.
Unfortunately, my tumors grew while on captem.

I’m now on FolFox. GI symptoms not as bad but I have really bad neuropathy in my hands and other annoying symptoms after 2 rounds. Don’t know yet whether it’s shrinking tumors.

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@djchambers
I am sorry to hear of all of the side effects from the Captem treatment. It is good that you are having fewer GI problems with FolFox. When will you have a follow-up scan to see how well the FolFox is working?

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Profile picture for Teresa, Volunteer Mentor @hopeful33250

@djchambers
I am sorry to hear of all of the side effects from the Captem treatment. It is good that you are having fewer GI problems with FolFox. When will you have a follow-up scan to see how well the FolFox is working?

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@hopeful33250
Thanks for your note. I don’t have any date for a CT scan. They told me it’ll be a few months.

I too am glad I don’t have the G.I. problems with the infusions. But the pain in my hands is close to intolerable. So I’m not sure it’s any better.

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Profile picture for laree @laree

Has anyone else experienced, Gerd, swallowing problems, asphoguitis after a few months of Captem? Also High glucose, type 2 diabetes from chemo medication. Anyone having good results with Everlomis? Thank you for any thoughts.

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@laree, how is your husband doing? Has he seen a diabetes educator to get some guidance on managing his glucose levels while on chemo? Perhaps an oncology dietitian consult could help with his additional side effects.

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Had Y90 radiated beads some 7 weeks ago for 2” diameter liver cancer, had no side effects and first CT Contrast scan showed about 70% of the tumour is destroyed, no sign of spreading and surgeon says it is the best result he has seen for my age 83 plus size of the tumour. He and nuclear radiologist both agree it exceeds their expectations and should all be gone by this Xmas at the latest! Everything worked 110% perfectly! Plus as a bonus, the liver has already started to regenerate where there was minor damage!

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My husband had a 50% tumor burden in his liver when he was diagnosed in 2008. He had y90 in 2010 and it killed nearly all of the tumors. The rest remained stable for over 10 years. During that time he was receiving lanteotide injections and was on everolimus for 3 years due to enlarged lymph nodes.

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Profile picture for airbusa380 @airbusa380

Had Y90 radiated beads some 7 weeks ago for 2” diameter liver cancer, had no side effects and first CT Contrast scan showed about 70% of the tumour is destroyed, no sign of spreading and surgeon says it is the best result he has seen for my age 83 plus size of the tumour. He and nuclear radiologist both agree it exceeds their expectations and should all be gone by this Xmas at the latest! Everything worked 110% perfectly! Plus as a bonus, the liver has already started to regenerate where there was minor damage!

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Hello @airbusa380 and welcome to Mayo Connect. I appreciate you sharing about the good results you had with the Y90 treatment. Having a 70% tumor reduction is a great result.

How were you feeling prior to the Y90 treatment and how are you feeling now?

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Never knew I had it and it could be up to 5+ years old. I’ve been totally asymptomatic during and after the Y90 and had no side effects whatsoever! Surgeon says it is totally curable although the will be some “housekeeping” to do like ablative procedures to get rid of it all. Im lucky insofar as the tumour is encapsulated inside an outer skin and apparently this is good as after 3 PET scans there is no sign of its spreading outside the liver. Thanks for reply and wishing you the very best!

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Profile picture for lindabees @lindabees

My husband had a 50% tumor burden in his liver when he was diagnosed in 2008. He had y90 in 2010 and it killed nearly all of the tumors. The rest remained stable for over 10 years. During that time he was receiving lanteotide injections and was on everolimus for 3 years due to enlarged lymph nodes.

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That’s great news as it appears that with a top medical team the successful recovery rate is around 95%. Mine never spread outside the kidney that being a good thing they tell me. Hope he has many years ahead of him!

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