Has anyone found a treatment that helps with peripheral neuropathy?

Posted by bigjohnscho @bigjohnscho, Jul 1, 2025

I suspect that everyone on this forum has been searching for a medication that helps their neuropathy and even though you no that all the internet claims are false we continue to waste hundreds of pounds. Desperation is a powerful force. Has any one been fortunate enough to find a genuine treatment. I just can’t believe that there are so many awful people who prey on our vulnerability and knowingly orchestrate such elaborate scams.

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Profile picture for charliestephen @charliestephen

Nortriptylene, R-Alpha Lipoic Acid, turmeric, and magnesium glycenate have greatly helped reduce the pain from my foot neuropathy. Exercise seems to help too, and I gave up alcohol two years ago.

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@ch

arliestephen

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Profile picture for goodguy55 @goodguy55

I just seen that prednisone can make a difference, but there's side effects! Maybe check it out if you're interested! Hope you feel better!

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@goodguy55 I’m on high dose prednisone for an autoimmune condition; it developed during this treatment.

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Profile picture for tatiana987 @tatiana987

I have found a treatment that works for me. It is a kind of physical therapy called the McKinsey method. I believe the particular move that made me realize it actually worked was called neural threading. I can breathe and sleep better. Maybe that is part of the relief I feel. Unfortunately, my therapist was part of a business model with policies that focus on profit rather than healing, so I am no longer with her, but will find another practitioner.

If you try to find this, be sure the person is fully certified to do the McKinsey method. I wasted time on therapists who were kind of half qualified. Also imo you need a therapist who is physically bigger than you are. She or he needs to be able to move your limbs in ways that involve rather large spaces.

I doubt very much that the therapists or people who teach the method claim that it cures PN. I am just saying it works for me. Maybe my problem is not the same as yours. Who knows?

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@tatiana987 I am unfamiliar with that therapy, but what I have noticed about PN is that it makes any other inflammatory problem you might have worse, such as tendonitis, arthritis, etc. Therapies that can help with those issues may not specifically address PN, but they are very helpful nonetheless.

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Profile picture for casd57 @casd57

Haven't found anything that really helps...in fact somethings that are suppose to help actually feel like it makes it worse... Like ALA....Nitric Oxide...
Little scared of Vitamin B12 because we are told too much can cause your neuropathy to be worse??
What I know... I don't remember having this before Covid... So I think mine is Covid related, This year..yea it took this long for me to figure out...Heat makes it worse, like a hot tub, shoes that are ventilated well...or soft enough
luckily my job isn't on my feet all day...I can sit for minutes and let my feet calm down before I have to go again...
If I had a job that kept me on my feet all day...I would have to retire or change jobs, and at 69years old I prefer to stay here and retire from this one...
There are good days....good nights and there are bad.. If its a bad night, my feet up to my knees will hurt and I found if I put my feet out of the cover into the cool air of the room it helps...
I've tried peptides...probably didn't give them a fair chance... might try again ARA290....if you would like to research it...
I guess I'll try Vitamin B12 METHYLCOBALAMIN.... I'll try anything at this time..

Good Shoes help...... NB 1080 are like walking on mashmellows..... Hokas Cliftons... I also like Skeckers Slip on's MAX Comfort but you need to try them because the comfort isn't always the same with Skeckers

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@casd57 Have you tried KURU's? I have a pair I like, just curious how they might compare to the others you mentioned.

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Profile picture for casd57 @casd57

@deanhobart
Your right...I blame it on Covid but it was really covid induced, It was alcohol we drank more during that time...like a couple of boxes a week... Don't worry we have stopped that long ago... and after some trial an errors(noticing that it would flair up when I drank a little alcohol more than one day in a row ie.., weekends)
But since start TIRZ GLP-2 my desire for it has dropped and I barely drink now and my feet appreciate it..but they still flair up after about 1800 steps... So its not gone...

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@casd57 I too have noticed a relationship between alcohol and PN pain. It's hard to describe, but primarily just an uncomfortable feeling. In my case, burning tongue/mouth rules out wine anyway due to the acids.

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Profile picture for mikead63 @mikead63

For me, having been diagnosed with IPN in January, what has helped includes:
1. One prescription drug - Gabapentin - which I take 2-3 hours before bedtime;
2. Over the counter medications - R-Lipoic Acid, Magnesium Glycinate and a number of additional vitamins recommended by a number of top rated medical journals.
3. Exercise every day if even for 15 minutes. If you can, move your body, especially walking.
I didn't list the amount of the above medications because you need to start off slowly until you find the right dosage for you. BUT, let me make this clear - what I take has been a big help for me but I'm not a doctor and, what works for me doesn't mean it will work for you!
P.S. Don't waste your money on all the scams on the internet - No matter what anyone says - There is no cure. If there was, you would have heard that already from Mayo Clinic, Harvard Medical, Cleveland Clinic etc. etc,, already!!!

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@mikead63 Agree. Go to a specialty clinic/hospital. All treatments are palliative, not curative.

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Profile picture for casd57 @casd57

Haven't found anything that really helps...in fact somethings that are suppose to help actually feel like it makes it worse... Like ALA....Nitric Oxide...
Little scared of Vitamin B12 because we are told too much can cause your neuropathy to be worse??
What I know... I don't remember having this before Covid... So I think mine is Covid related, This year..yea it took this long for me to figure out...Heat makes it worse, like a hot tub, shoes that are ventilated well...or soft enough
luckily my job isn't on my feet all day...I can sit for minutes and let my feet calm down before I have to go again...
If I had a job that kept me on my feet all day...I would have to retire or change jobs, and at 69years old I prefer to stay here and retire from this one...
There are good days....good nights and there are bad.. If its a bad night, my feet up to my knees will hurt and I found if I put my feet out of the cover into the cool air of the room it helps...
I've tried peptides...probably didn't give them a fair chance... might try again ARA290....if you would like to research it...
I guess I'll try Vitamin B12 METHYLCOBALAMIN.... I'll try anything at this time..

Good Shoes help...... NB 1080 are like walking on mashmellows..... Hokas Cliftons... I also like Skeckers Slip on's MAX Comfort but you need to try them because the comfort isn't always the same with Skeckers

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@casd57 Thanks for your input. I too am extremely heat sensitive. I refuse to use the term «presyncope » for what I experience. I call it « heat sickness ». Speaking accurately helps doctors, I think, and there are many possible causes for presyncope. For me, heat is always the major factor.

One question I have in your approach to self treatment is this: are you cooling your core enough? It sounded to me like you might only cool the affected foot or other area. In my experience, core cooling has much better effects. For example, a cool/cold swim might help far more than is obvious, not wading in cold water, but full body immersion.

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Profile picture for karenjaninaz @karenjaninaz

@goodguy55 I’m on high dose prednisone for an autoimmune condition; it developed during this treatment.

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@karenjaninaz Have you tried alpha lipoic acid 600 mg once a day - I have sensory idiopathic neuropathy and helped me 90%. Get it at health food stores. I could not take gabapentin or Lyrica - the fatigue was too great. Good luck.

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I’m ready to try it but I’m going through a treatment for giant cell arteritis. I asked my doctor if I could take ALA and he said yes. I’m just waiting to see how I react to the injections I need to take. How long did it take you to get results?

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Profile picture for gnocchi @gnocchi

@karenjaninaz Have you tried alpha lipoic acid 600 mg once a day - I have sensory idiopathic neuropathy and helped me 90%. Get it at health food stores. I could not take gabapentin or Lyrica - the fatigue was too great. Good luck.

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@gnocchi Sound too good to be true. What were you pain level before and after taking this supplement?

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