1. < Polymyalgia Rheumatica (PMR)
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Anyone having a lot of problems while taking leflunomide?

Posted by lindaadel @lindaadel, Aug 3, 2024

I started leflunomide two months ago and I’m having a lot of Side effects! Loss of appetite losing weight nausea less energy etc. right now my rheumatologist said to stay off it one month come back for an appointment in one month. The only positive is that my joints are not as bad as they were. every day I feel differently some days I feel a lot better than other days I never know! bottom line having PMR is no fun it’s like a roller coaster!!! no fun!!!

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heatherjane59 | @heatherjane59 | Jul 30 5:33am
In reply to @vbdunn "I have been on prednisone for 10 years for PMR and every time I go below..." + (show)
Profile picture for vbdunn @vbdunn

I have been on prednisone for 10 years for PMR and every time I go below 5mg I have a relapse. My rheumatologist started me on Leflunomide 3 months ago to help me get off of prednisone because of osteoporosis and it has been a miracle. No more morning stiffness while awaiting the morning prednisone to kick in and no initial side effects
Now my liver enzymes are significantly elevated
Has anyone else had this experience?

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@vbdunn Thats good to hear that it’s working for you. Ive also been put on Leflunomide a few weeks ago after 4 1/2mths on methotrexate which gave me such dreadful side effects, i couldn't function for 3 days out of each week. Very happy to be off it. So far so good with the Leflunomide, im having some side effects but minor compared to my methotrexate experience. Due to have my first blood test next week to check on liver and kidneys. I was told i wouldn’t feel much relief for at least 8 weeks.

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