With a Decipher score of 0.29 has anyone done Active Surveillance?

I don’t know if just that one data point is enough to make that decision. By the time a person had a decipher score obtained from biopsy tissue there typically are many more data points for a totality of a decision to be made. Having such a low decipher score could certainly be the tipping point in a AS decision but that is combined with results of PSA’s, Gleason scores, Mri’s, Pet, Biopsy pathology.

What did your biopsy show? What was the Gleeson score? What percentage of four was found in any cores that had a 4.

How many total cores were 3+3 or higher?

Were any of these things found in the biopsy intraductal, ductal, large cribriform, Seminal vesicle invasion, EPE or ECE. (Extraprostatic extensions extra capsular extensions). They can make the cancer much more aggressive.

His biopsy showed a 3+4 on 1 spot and there were 3 spots with a 3+3 Gleason score. They did a biopsy on 12 spots.
The Decipher score came back Friday 0.29 on the 1 spot. At this time the cancer is not outside of the prostate gland according to the MRI and the Urologist. He is going to the best in Kansas City for a Urologist. His last PSA score was a 5.3 and it has gone up in the last 6 months. He is only 65. Jeff you are wonderful to reply I can’t thank you enough.

@miggie
If the other details in the report on the biopsy are all negative regarding for instance the things Jeff was mentioning, I would think he would be a good candidate to discuss AS with his Doctor

@wheel1
Thank you for your response. I appreciate it.

@miggie
He should get an Hereditary, genetic test. Getting prostate cancer at that age can frequently be due to a genetic problem. I got it at 62 and it was because of the fact that I have BRCA2 a genetic problem.

That’s pretty low level prostate cancer. We need to find out what percentage of four there was in that one core That had a 3+4. If it was below 10%, then he could definitely go on active surveillance. Have the doctors talked to you about that?

Not sure if you didn’t post this somewhere else since there was another message where somebody had a .29 decipher score and was asking about what to do.

Here are some videos that discuss going on active surveillance with similar situations to what you have talked about. The last one probably would be the most relevant.

Here is a video with Dr. Laurence Klotz, one of the experts on active surveillance. He can give you answers as to why you would or would not be a good candidate for active surveillance.

Active Surveillance for Intermediate Risk Prostate Cancer w/ Dr. Claire de la Calle | Ep. 288

@jeffmarc
Jeff the Carcinoma is approximately 20% that is the 3+4. A 3+3 is 10%, Another area is 3+3 is 5% and another is 3+3 is 20%. I talked to him about the Genetic Testing. The Dr. says that his prostate is not enlarged. That was probably me that posted about the Decipher Score of 0.29. I am a newbie to Mayo Connect so I so appreciate everyone's kindness and support. I will watch the videos. I am just a friend that he has trusted sharing this diagnosis with.

@miggie
There is no relationship between prostate size and genetic problems. My prostate was never enlarged and I have BRCA2.

@miggie

I am in a similar situation regarding my biopsy (2 of 16 cores, a 3+3 and a 3+4 with 10% being 4) and am awaiting my Decipher score. My surgeon said that I may be able to do AS, but is actually starting a second phase of a clinical trial using aquablation which I may be a candidate for at Johns Hopkins. I believe that there are other centers with similar trials, maybe his in KC. Might be worth checking out. Only 2/3 in the trial get the aquablation with the remainder on AS to compare results.

The aquablation offers many advantages over RARP - not invasive (trans urethral), very little comparable side effects (ED, incontinence), shorter hospital stay. I'm just hoping that my co-morbidities don't disqualify me.

Good luck!