Yes, I have had two flare ups since being on brinsupri. And I have learned that I have to do airway clearance, regardless of whether it feels like I have any to produce. It is harder to produce it, it seems thicker. Put the trade off is worth it.I'm not coughing my brains out every day and all night. I very rarely cough, so when I find I am coughing more, I know, I need to work harder at getting the sputum up and out. I have been on brinsupri since last november and i'm currently in the hospital with a flare up that was not responding to the usual oral meds. I'm on intravenous round the clock.