Spinal osteoporosis after 10 months on ADT

Posted by drew2021 @drew2021, Jul 15 6:24pm

I went on ADT (Lupron + Nubeqa) in September 2025, 9 months after my prostatectomy and subsequent rise in PSA. (I also had radiation therapy in Nov.-Dec. 2025.) My DXA bone scan a few days ago shows that my spine now has osteoporosis, and I wanted to ask others here who have had similar experience what you've done about it, and how it has gone. I still have 14 months left on my ADT therapy plan, and will be seeing my oncologist tomorrow to discuss all this.

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Profile picture for grandpun @grandpun

My orthopedic doc and urologist/oncologist now accept the below:
Ortho advised only needing Ca in the normal range but taking large supplements of C and D3. Both at least 6,000 IU per day.
Reason is, the D3 and C activate the body's ability to use the Ca for bones. Excess Ca just gets washed out by the kidneys - which can also raise risk of kidney stones.
I'm also on Prolia twice a year for life due to osteoporosis.
At first, onco kept advising Ca but after the above explanation he ok'ed moderate/normal Ca if any and encouraged D3 in particular.
This was all triggered by 5 compression fractured Thoracic vertebrae (those were a "12" pain on the 1 - 10 scale) a year and 1/2 after finishing 2 years of Lupron.
Be sure to consult a orthopedic surgeon of high repute if using any ADT.

PS: my hospital has a "protocol" that DEXA bone scans don't evaluate the spine; only one leg and on arm. So my osteoporosis was a nasty surprise. If I ever get another DEXA it will be at another provider.

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@grandpun Thank you for your story--I'm sorry it has been so difficult, and 1.5 years after Lupron at that. The DXA should definitely include the spine.

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I saw my oncologist this morning, and he has put me on Zometa starting in 3 weeks. My bone density apparently is already below average for my age (68) , so that may account in part for.the osteoporosis. Thank you everyone for your help, and good health and luck to all.

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Profile picture for surftohealth88 @surftohealth88

@drew2021
If I may just suggest doing some exercises that involve small bouncing moves (like going up and down one step , or using small trampoline, or doing small bunny jumps ). Studies were done mostly for women and osteoporosis but now there were done for men on ADT also (Australia) and the same effect was noticed - those kind of small "bounces" cause bone to regrow. Somehow those small "impact" moves cause bones to grow stronger.

Now that you have weakened spine : ((( , please ask you doctor (or even better PT therapist) if those kind of exercises are too much for your spine. If they are not, than it might be worth trying them.

Wishing you all the best and super fast reversal of you a bone loss 🍀

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@surftohealth88
Did they say anything about the fact that just walking at a fast rate for a distance would be equivalent to bouncing?

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Profile picture for drew2021 @drew2021

@gently and @jeffmarc, thanks so much for your thoughts. I also plan to ask my doctor, who is very expert on these things, why I didn't have a baseline bone scan at the start of treatment, as I was shocked at how fast the osteoporosis happened. My PSA is 0.006 so at least that is going well.

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@drew2021 I was in your shoes albeit just osteopenic. BMD loss was probably ongoing for me prior to PCA treatment. I took Prolia for 2 years while on ADT, and it worked without any bad SE's.

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Profile picture for Jeff Marchi @jeffmarc

@surftohealth88
Did they say anything about the fact that just walking at a fast rate for a distance would be equivalent to bouncing?

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@jeffmarc my understanding is that the bouncing, skipping, small jumps should be done in non cushioned shoes on a hard surface. The cushion cushions the jolt the bones need. I've found Dr Robert Newton's book, "My Exercise Medicine for Cancer" to be invaluable. He also discusses this at the 2025 PCRI conference. His hour long talk is available on YouTube.

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Profile picture for Jeff Marchi @jeffmarc

@surftohealth88
Did they say anything about the fact that just walking at a fast rate for a distance would be equivalent to bouncing?

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@jeffmarc

Any movement that we do standing up is helping since our own weight is putting pressure on our skeleton but if one wants to build bones they need some extra stimulation.

Special bouncing moves are called " Plyometric exercises" and they specifically require bouncing.

Now - one has to start slow ! And one has to know one's own limits. For seniors it is very important to take care of joints and spine and not make any sudden moves without warming up. It is also important to know that moves can be done holding onto railing or chair or any other stable surface if one has trouble with balance. Twisting fast moves should be avoided if one has problems with spine and big jumps avoided if one has painful joints of any kind.

There are numerous videos with plyometric exercise but everybody - please stick with ones for seniors if you have any skeletal issues. There is no need to do advanced moves like jumping onto the step , or twist and jump etc etc - absolutely no need to do those !!!

Bouncing can be done even without jumping off the ground. It is NOT true that one needs hard surface either (as somebody mentioned). Yes- the harder the impact the faster bones "get the idea" to grow, but for seniors slow and steady has the same benefit and prevents injury.

Here is one example of plyometric exercise :
https://www.google.com/search
Please all notice that first 2 exercises do not even require jumping ! Others are gentle bouncing and the last is squat jump BUT the descent is to squat again so there is no hard impact on the knees.

If somebody has trouble with joints it is OK to do this on soft mat. As I said, growth will be slower but it will happen .

If one is regularly involved in sports and has not trouble with joints and has no osteoporosis or osteopenia - than of course do bigger jumps, jumping jack, jump the rope, etc etc.

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Profile picture for surftohealth88 @surftohealth88

@jeffmarc

Any movement that we do standing up is helping since our own weight is putting pressure on our skeleton but if one wants to build bones they need some extra stimulation.

Special bouncing moves are called " Plyometric exercises" and they specifically require bouncing.

Now - one has to start slow ! And one has to know one's own limits. For seniors it is very important to take care of joints and spine and not make any sudden moves without warming up. It is also important to know that moves can be done holding onto railing or chair or any other stable surface if one has trouble with balance. Twisting fast moves should be avoided if one has problems with spine and big jumps avoided if one has painful joints of any kind.

There are numerous videos with plyometric exercise but everybody - please stick with ones for seniors if you have any skeletal issues. There is no need to do advanced moves like jumping onto the step , or twist and jump etc etc - absolutely no need to do those !!!

Bouncing can be done even without jumping off the ground. It is NOT true that one needs hard surface either (as somebody mentioned). Yes- the harder the impact the faster bones "get the idea" to grow, but for seniors slow and steady has the same benefit and prevents injury.

Here is one example of plyometric exercise :
https://www.google.com/search
Please all notice that first 2 exercises do not even require jumping ! Others are gentle bouncing and the last is squat jump BUT the descent is to squat again so there is no hard impact on the knees.

If somebody has trouble with joints it is OK to do this on soft mat. As I said, growth will be slower but it will happen .

If one is regularly involved in sports and has not trouble with joints and has no osteoporosis or osteopenia - than of course do bigger jumps, jumping jack, jump the rope, etc etc.

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@surftohealth88
What concerns me about doing this is that my back has problems that keep coming back. I have lower back pain that I can’t be sure wouldn’t be aggravated by doing this. I also have a hip that was replaced that is not real happy all the time. Sometimes when I walk, it really grabs me and I have to stop for a moment.

And then I’ve got a laminectomy in my neck and a plate back there and I’ve gotta be careful. I don’t bounce that around too hard..

I think I’ll just stick to walking.

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Profile picture for Jeff Marchi @jeffmarc

@surftohealth88
What concerns me about doing this is that my back has problems that keep coming back. I have lower back pain that I can’t be sure wouldn’t be aggravated by doing this. I also have a hip that was replaced that is not real happy all the time. Sometimes when I walk, it really grabs me and I have to stop for a moment.

And then I’ve got a laminectomy in my neck and a plate back there and I’ve gotta be careful. I don’t bounce that around too hard..

I think I’ll just stick to walking.

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@jeffmarc

Absolutely - I would stick to walking too if I had spine or hip problem. 👍
Bouncing can especially aggravate neck because neck has that special curvature which actually serves as an "amortization mechanism".
Does walking up hill and down hill cause any pain for you ? I am asking because when we go downhill there are a lot of "impact" movements.
Also, going down the stairs would make small "impact" bounces which would be enough for bone health.
I read somewhere that there are even some pool exercises - I will try to find those and I will post if I find a video.

PS: Just finished Googling - there are a ton of them but mostly designed for athletes (performance enhancement). BUT, watch them and see if there are any moves that you can modify to your level of comfort and perhaps do in a pool. I think that you once mentioned that your son is PT ? Perhaps he can help you find what can work for you <3. The good thing is that you are on bone building meds , so you are probably safe even without these exercises.

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Due to a narrow frame and drug therapy for another condition, I was osteopoenic for many years prior to my cancer diagnosis. ADT (Lupron, abiraterone, prednisone) pushed me over the edge into osteoporosis. Over the course of three years, I was given three Reclast infusions. I did a lot of walking and weights at first, but that became less as I developed very painful neuropathy in both legs and feet (several different specialists unable to identify exact cause) and ADT fatigue set in in earnest in the second year of ADT. Since completion of ADT, I’ve become more active again. The Reclast has been effective, and the osteoporosis has been reversed. I am still ostepoenic, but my rheumatologist says that the Reclast should continue to have a positive effect, even though it’s left my system. Even the neuropathy has lessened, although I’m still on Gabapentin to control the pain.

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Just had my first DEXA scan, and I'm OK for now. Recommended I start taking a Calcium supplement along with Vitamin D in the morning and Magnesium supplement at night.

ADT messes with everything, but there are things you can take to offset the damage it does.

Hang in there - you got this. 🙂

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