@mmkennedy Similar story to yours. I grew up in the 1950s/60s near a chemical plant. Too many people at my 50th class reunion with blood cancers for me to think it's a coincidence.

The HU helped with symptoms at first. Been on it x 8 years. I also have constipation. Certain yoga exercises + water + more fiber help.

I am supposed to have cardiac surgery and have to go off HU for two weeks prior. So if that goes thru, we'll see how I feel off HU.