PSA undetectable but testosterone remains negligible

@anosmic1 The general rule of thumb for T recovery following ADT (with the exception of Orgovyx and Firmagon) is to expect it to take about 50% longer than the ADT was planned for.

In my case, I had two 3-month injections of Eligard (April & July); expected T recovery in October, but it didn’t recover for 3 additional months (January of the next year).

With your last injection in October, you’re right at that ~9 month mark. Your next PSA test will be telling.

It’s important to know your baseline T numbers. That helps in troubleshooting should your later PSA or T numbers become unusual.

(I recall telling my wife (in January 2022), that I thought the Eligard was wearing off because I was beginning to lift heavier weights at the gym. Since I wasn’t due for another “official” bloodwork for another couple of months, I self-ordered another PSA & testosterone test (out of curiosity), and those came back as 0.13 & 403.0, respectively, meaning that everything was going exactly as expected - that is, PSA staying low and testosterone increasing as the Eligard was leaving my system.)

@anosmic1 The general rule of thumb for T recovery following ADT (with the exception of Orgovyx and Firmagon) is to expect it to take about 50% longer than the ADT was planned for.

In my case, I had two 3-month injections of Eligard (April & July); expected T recovery in October, but it didn’t recover for 3 additional months (January of the next year).

With your last injection in October, you’re right at that ~9 month mark. Your next PSA test will be telling.

It’s important to know your baseline T numbers. That helps in troubleshooting should your later PSA or T numbers become unusual.

(I recall telling my wife (in January 2022), that I thought the Eligard was wearing off because I was beginning to lift heavier weights at the gym. Since I wasn’t due for another “official” bloodwork for another couple of months, I self-ordered another PSA & testosterone test (out of curiosity), and those came back as 0.13 & 403.0, respectively, meaning that everything was going exactly as expected - that is, PSA staying low and testosterone increasing as the Eligard was leaving my system.)

@brianjarvis

15 months after my last 3-month Lupron shot and I have a 125 testosterone and of course no libido or erections. I was on Lupron for only 4 of the recommended 18 months but had to stop because of very severe and painful headaches, muscles and bones. I felt like I was dying and i think I would have if I had another Lupron shot. The side effects began to wane after 14 months, but they are still present.

I just returned from the surgeon with a PSA of 0.02 and he said he likes to see it at 0.01, so I am on track for a repeat PSA and visit to him in 2 months. He said, " that maybe some cells had jumped the gate", so as with a Gleason score of 3+4, I am at more risk than my brother, whose score was 3+3.

@pesquallie What was your baseline T level; & how old are you?

Both of those often play a role in T recovery.

@brianjarvis

Over the 10 years before Lupron, I averaged a testosterone level of 268, and I will be 84 this week. So, after 15 months since my last 3-month Lupron injection, I have regained about 50% of what was already a low testosterone level with major ED issues. I am now interested in ways where I can raise my testosterone to rid myself of all the side effects I still have.