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PSA undetectable but testosterone remains negligible
Prostate Cancer | Last Active: 21 hours ago | Replies (20)Comment receiving replies
Over the 10 years before Lupron, I averaged a testosterone level of 268, and I will be 84 this week. So, after 15 months since my last 3-month Lupron injection, I have regained about 50% of what was already a low testosterone level with major ED issues. I am now interested in ways where I can raise my testosterone to rid myself of all the side effects I still have.
Replies to "@brianjarvis Over the 10 years before Lupron, I averaged a testosterone level of 268, and I..."
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@pesquallie Data show that older age results in significantly slower and less frequent testosterone recovery after stopping ADT compared to younger men. Recovery time also depends heavily on the duration of the hormone therapy and starting (baseline) testosterone levels.
> https://goldmanlaboratories.com/blogs/blog/testosterone-and-cancer-survivors-men-60
> https://www.smsna.org/patients/news/after-adt-testosterone-levels-don-t-always-recover
> https://www.curetoday.com/view/testosterone-recovery-in-prostate-cancer-may-depend-on-adt-intensity
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Something else to discuss with your medical team —>
There is a school of thought that your "menopausal" symptoms (hot flashes, fatigue, and low libido, etc.) may not only be caused by low testosterone (due to hormone therapy), but also low estrogen that triggers many of these specific side-effects.
In men, a portion of testosterone is converted into estradiol (a form of estrogen). When testosterone drops (due to hormone therapy), the body's estrogen supply naturally drops with it. A chain of events occurs:
> a testosterone deficiency automatically means a lack of the building blocks needed to make sufficient estrogen.
> When men experience severe hot flashes, clinical studies have shown that administering estrogen alone minimizes their symptoms (https://pubmed.ncbi.nlm.nih.gov/10654902/; https://www.wellrx.com/news/estrogen-in-men/)
Again, something to discuss with your medical team.