Prolia and its side effects.

Posted by canadiancc @canadiancc, Sep 1, 2023

Background: I’m a 79 year old female. Hip replacement in 2015; right knee replacement in 2017; left knee replacement in August 2022. I have arthritis in several parts of my body, including both hands.
A recent bone density test showed I have significant bone loss in parts of my body. Wasn’t able to get appointment with endocrinologist for 4 months. GP prescribed Risedronate 35mg taken once a week. Noticed joint and muscle pain became worse. Taking Tylenol for Arthritis to take the edge off.
Appointment with endocrinologist 3 days ago; she strongly recommended I start having Prolia injections. During my appointment she issued a prescription to my drugstore for Prolia to be started the next day.
Once home, I felt I should look for information on Prolia, only checking unbiased websites. What I found, including patients’ stories about their negative experiences, was unsettling. I’ve heard of doctors saying ‘don’t take any notice of Dr Google’, I’ve found that reliable information and supporting data is available on the internet, including that of the Mayo Clinic. Gut feeling and supporting evidence supported my decision not to start Prolia injections.
I would like to know what percentage of those who tolerate Prolia also have arthritis. Conversely, what percentage of those who’ve had adverse reactions to the drug have arthritis.

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pez01 | @pez01 | May 8 8:51am

I have been taking Prolia for a few years now and I have never suffered any side effects. Like all medicines there is a list of side effects but that doesnt mean you will get them. I get my shot twice a year and never feel any different after shot than before I am 87 years old and have lots of aches and pains from aging alone. Please dont be afraid to try this mediicine and judge it for yourself

pattyannblack | @pattyannblack | May 8 9:56am

I had my first dose on Feb 16th this year. I am just starting to feel a bit better (three months later) but still experiencing symptoms of pain in my feet, knees, wrists, and lower back. I also have sinus problems like you. It is a very slow recovery. The half life of this drug is 25 to 32 days (so I thought I would feel better in a month) but this drug continues to work on your bones for up to 4 months. I have only started to feel "marginally" better in the past two weeks. I would have one reasonably good day followed by the return of full symptoms. So far this week, I am "marginally" better but not close to being normal yet. I also, like you, am very sensitive to drugs. I also take the smallest dose possible to drugs like allergy medication. I have also had serious reactions to the smallpox vaccine and penicillin. My daughter is allergic to the tetanus vaccine. To be honest, this drug has caused me to be housebound and I have been unable to do even the basic routines of normal life. I will never take it again. Thank you so much for replying. I so appreciate that. I am not the only one. Thank You.