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JAK2 Essential Thrombocythemia (ET) Treatment

Posted by goodcheers @goodcheers, 3 days ago

I recently came upon a fairly recent article about the monoclonal antibody INCA44989 treatment for JAK2 ET. It supposedly has a roughly 70% positive response rate, and with a low toxicity profile, meaning minimal side affects. This is great news for all of us who have been afflicted with this unfortunate blood disorder.

I searched for a discussion about this but nothing came up. I'm wondering if anyone reading this may have some experience or information on this subject.

Thanks

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janemc | @janemc | 4 hours ago
In reply to @gigi05 "So I just got the results from a blood test yesterday --C-reactive protein is indeed elevated..." + (show)
Profile picture for gigi05 @gigi05

So I just got the results from a blood test yesterday --C-reactive protein is indeed elevated this time. Grrr --no clue of course of the reason, and not sure right now on my plan of action to combat this. Anyone ?? Testing for inflammation? which tests? Things that worked??

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@gigi05

Wondering if you're taking a daily antihistamine, gigi05?

If so, I'll pass on a tip from my Nurse Practitioner: Take the pill at night, then boost its efficacy with a Flonase-type product in the morning.

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mjervis | @mjervis | 3 hours ago
In reply to @eileen11108 "@janemc @gigi05 I am glad this topic has been brought up. I am 82 and have..." + (show)
Profile picture for eileen11108 @eileen11108

@janemc @gigi05
I am glad this topic has been brought up. I am 82 and have taken HU since 2022 for ET JAK2. I only take 500 mg four days a week. I find my arthritis much worse…mornings are especially hard. I do not know if it is the toxicity of HU, the Eliquis blood thinner, or just old age. Since. I am on a blood thinner I can only take Tylenol.
Best wishes, Eileen

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@eileen11108 I am 77 and have only started on HU since Feb, I am on 1000 per day and as time has gone on I am suffering from stiff and sore joints so I am blaming HU. I will see my haematologist next week and maybe I can lower the dose. But I also have melanoma cancer so as my oncologist says I am a complex patient! There are no answers for some things and we just have to do the best we can.

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gigi05 | @gigi05 | 1 hour ago
In reply to @janemc "@gigi05 Wondering if you're taking a daily antihistamine, gigi05? If so, I'll pass on a tip..." + (show)
Profile picture for janemc @janemc

@gigi05

Wondering if you're taking a daily antihistamine, gigi05?

If so, I'll pass on a tip from my Nurse Practitioner: Take the pill at night, then boost its efficacy with a Flonase-type product in the morning.

Jump to this post

@janemc Interesting! I recently started feeling like I have some seasonal allergies, but as I am new to that, I had not even thought of antihistamines. I will try this. Great suggestion. And, curious, what made you even think of this?

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janemc | @janemc | 1 hour ago
In reply to @gigi05 "@janemc Interesting! I recently started feeling like I have some seasonal allergies, but as I am..." + (show)
Profile picture for gigi05 @gigi05

@janemc Interesting! I recently started feeling like I have some seasonal allergies, but as I am new to that, I had not even thought of antihistamines. I will try this. Great suggestion. And, curious, what made you even think of this?

Jump to this post

@gigi05

nohrt4me gets all the credit!

I started following her advice on this some time ago.

Our ET platelets are so misshapen that they can trigger our immune response.

Lucky us!!

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