Good news and a question about T levels

Posted by chippydoo @chippydoo, 10 hours ago

Got my 1-year post radiation and ADT blood work yesterday and the good news is after 4 years my PSA is finally undetectable which is great news to me. 3 months after finishing tx. my T had recovered to 230. Started Tx. at 250 so a low T guy is my norm. My test result this week stated my T is now 175 and I am feeling the side effects of this. Question- Is this normal after ADT and radiation or pointing to a Pituitary Gland issue? Thinking of persuading an appointment with an Endocrinologist for further testing. Any experience with this out there? Thanks

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brianjarvis | @brianjarvis | 7 hours ago

Great that your PSA is so low!

You indicate being 1-year post-radiation with undetectable PSA. That’s unusual to be undetectable 1-year post-radiation unless:
> it was salvage radiation, or
> there is still ADT in your system.

But, since you say that your T is recovering, the ADT must be out of your system. Was your radiation primary or salvage?

It is “normal” following ADT for T levels not to return fully to where it initially was. But, since yours started out low (250 ng/dL), “normal” can be lower than that.

T recovery from ADT can depend on a number of things:
> how old are you? (Age matters)
> how long were you on ADT?
> how long have you been off of ADT?

chippydoo | @chippydoo | 6 hours ago

In reply to @brianjarvis "Great that your PSA is so low! You indicate being 1-year post-radiation with undetectable PSA. That’s..." + (show)

@brianjarvis I had RP 4 years ago and never went undetectable. BCR after 2 years and treated with salvage radiation and 6 months of ADT. I used Orgovyx achieving low single digit T for 6 months. Finished July 2025. 3 months later my T recovered to 230. 250 was my starting point as I am a naturally low T guy.
I had my 1 year PSA and T test this week. My PSA is undetectable, Ultra sensitive test .014. My T has fallen to 175 which is my concern in 3 months. I will get retested.
Wondering if others have experienced their T falling after it almost being pre ADT levels a year later. This is my concern. Is it normal or do I need to see an endocrinologist for Pituitary Gland testing for other disease?
Interested in others experiences if this happened.

Jeff Marchi | @jeffmarc | 5 hours ago

I’ve heard many times from people That had their testosterone go up and then down, It seems to be a pretty common problem. It usually recovers after a few months.

Great to hear you have undetectable PSA without the drugs.