Has anyone found a treatment that helps with peripheral neuropathy?

Posted by bigjohnscho @bigjohnscho, Jul 1, 2025

I suspect that everyone on this forum has been searching for a medication that helps their neuropathy and even though you no that all the internet claims are false we continue to waste hundreds of pounds. Desperation is a powerful force. Has any one been fortunate enough to find a genuine treatment. I just can’t believe that there are so many awful people who prey on our vulnerability and knowingly orchestrate such elaborate scams.

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Profile picture for smiddy73 @smiddy73

Interesting. I've been told I have small fibre neuropathy. I've been through all the hoops, consulted neurologists and others.
I did read, on Facebook of all places, an article about vitamin b12 deficiency. In the UK a blood test is done checking possible culprits for your symptoms. Mine was, mainly, an ice cold sole of left foot but both affected; sometimes burning, always tingling.Maddening. Relief when in bed at night. This article said that the standard NHS test for b12 is flawed, as it measures total b12. There is active and non active b12. Only active should be measured. To cut a long story short I challenged my GP, no joy. So, eventually I oaid for a private test on active b12. It was 30% below the lowest on normal range. My GP checked this then put me on 6 loading doses of b12 over 2 weeks. I've had to continue pushing but,with neurological issues, the Nice ( NHS overseeing body), guidelines state that the injections should then continue every other day until no further improvement. That's where I am. It's early days but I'm hopeful.
I've been tested for pernicious anaemia but it was negative. However it seems that test doesn't pick up all cases so I'm thinking about next stepson this. PA is main cause of b12 deficiency. Not the only one though. Proton Pump Inhibitors taken long term are a cause too( that's used for acid reflux). And others.
I'll update in a few weeks..

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Thanks for getting back to me.
I am 83.5 with nil nerve or joint pain. But I have always eaten vitamin D
rich food and sunbathed a lot, so much so, that I have had skin cancer
removed. I learned that our older stomach had less acid. So less B12 is
extracted from food. Then most elders eat too little animal protein. B12 is
only in animal food.. B12 is made by soil bacteria utilizing the mineral
COBALT. The medical name for B12 is COBALAMIN. Wind blown soil coats grass.
Grazing animals get plenty B12 from grass coated with cobalamin. We eat
meat,so we get B12. Or should.
Too many elders eat mainly carbohydrates. They are cheap and convenient. Be
warned. ..
Alcohol reduces B12 absorbtion. B12 grows nerves insulation everywhere, in
our brain too.
Good luck.

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I feel the same way. And now there’s this AI. They will do anything for $.
Mardy

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I found one that completely got rid of my peripheral neuropathy while on it, but I'm not advising anyone to try it. It was serendipitous. A friend of mine at work mentioned that he took lithium to help with his ADD/ADHD. He and I are very similar in our ways and I thought that I would give it a try. I did not have a prescription for his lithium medication type, and knowing that it's an element, searched Amazon.com to see if there was a supplement available. I found one called lithium orolate and the reviews were positive from it helping mood, anxiety, etc., so I thought I'd give it a try. I took the 5mg dosage and by the second day, my PN was gone. It had blocked it better than gabapentin and THC/CBD prescribed by my pain Dr. Now the side effects because there is no free lunch, right? I lost most of my sense of taste and had to urinate a lot more often. I stopped taking it and my PN is back and my sense of taste is slowly coming back. I didn't see any comments in the reviews about people losing their sense of taste and after an AI search believe that my system is hyper sensitive to lithium. Others in the comment section said they had been taking it for years with no side effects. Anyway, I'm not suggesting anyone take it, but I am here to say it helped my PN better than anything I've taken yet.

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Profile picture for KG @levelup

I found one that completely got rid of my peripheral neuropathy while on it, but I'm not advising anyone to try it. It was serendipitous. A friend of mine at work mentioned that he took lithium to help with his ADD/ADHD. He and I are very similar in our ways and I thought that I would give it a try. I did not have a prescription for his lithium medication type, and knowing that it's an element, searched Amazon.com to see if there was a supplement available. I found one called lithium orolate and the reviews were positive from it helping mood, anxiety, etc., so I thought I'd give it a try. I took the 5mg dosage and by the second day, my PN was gone. It had blocked it better than gabapentin and THC/CBD prescribed by my pain Dr. Now the side effects because there is no free lunch, right? I lost most of my sense of taste and had to urinate a lot more often. I stopped taking it and my PN is back and my sense of taste is slowly coming back. I didn't see any comments in the reviews about people losing their sense of taste and after an AI search believe that my system is hyper sensitive to lithium. Others in the comment section said they had been taking it for years with no side effects. Anyway, I'm not suggesting anyone take it, but I am here to say it helped my PN better than anything I've taken yet.

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@levelup I suspect u r a senior. Nerves need vitamin B12 to maintain their insulation. B12 is extracted from foods that contain it in our stomach acid. Because us seniors have less stomach acid we have less B12 circulating. Those of us who eat plenty of B12 rich foods like liver ,mussels, don't loose their nerves insulation. METHYLCOBALAMIN is the best supplement.
COBA stands for cobalamin. That's a soil mineral that's supports B12 making bacteria. Wind blows it onto grass and we eat the animals.
That's why vegans have to take a supplement. Go for it. Eat better food.

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Profile picture for jamessaxo @jamessaxo

@levelup I suspect u r a senior. Nerves need vitamin B12 to maintain their insulation. B12 is extracted from foods that contain it in our stomach acid. Because us seniors have less stomach acid we have less B12 circulating. Those of us who eat plenty of B12 rich foods like liver ,mussels, don't loose their nerves insulation. METHYLCOBALAMIN is the best supplement.
COBA stands for cobalamin. That's a soil mineral that's supports B12 making bacteria. Wind blows it onto grass and we eat the animals.
That's why vegans have to take a supplement. Go for it. Eat better food.

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@jamessaxo yes, I'm 59, and you were right about the B12, the problem I had was that I had TOO much via B12 injections, plus, I wasn't watching the B12 I was getting in supplements (more on that further down in this paragraph). My B12 levels were 5x the safe upper limit when I finally had them tested and could have been higher than that, sadly. So, I'm now on the slow recovery phase which could take 6 months to a year. Pins and needles coupled with burning sensations when exposed to heat sources like sunlight, warm temps outside of air conditioned buildings, and the rise in blood pressure from anything like laughter to anger to fright triggers it. But I believe that it's getting better, however slowly. To your point, there is literature everywhere about the lack of B12 and neuropathy, but also misleading information everywhere that says that your system "gets rid of excess B12". This is correct, it does, but first (as you probably know since you are knowledgeable about B12) it's stored in the liver for later use. The lithium orolate worked as a nerve block for me, but losing much of my sense of taste was a bit harrowing.

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Profile picture for KG @levelup

@jamessaxo yes, I'm 59, and you were right about the B12, the problem I had was that I had TOO much via B12 injections, plus, I wasn't watching the B12 I was getting in supplements (more on that further down in this paragraph). My B12 levels were 5x the safe upper limit when I finally had them tested and could have been higher than that, sadly. So, I'm now on the slow recovery phase which could take 6 months to a year. Pins and needles coupled with burning sensations when exposed to heat sources like sunlight, warm temps outside of air conditioned buildings, and the rise in blood pressure from anything like laughter to anger to fright triggers it. But I believe that it's getting better, however slowly. To your point, there is literature everywhere about the lack of B12 and neuropathy, but also misleading information everywhere that says that your system "gets rid of excess B12". This is correct, it does, but first (as you probably know since you are knowledgeable about B12) it's stored in the liver for later use. The lithium orolate worked as a nerve block for me, but losing much of my sense of taste was a bit harrowing.

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Levelup
Thanks for your detailed reply. An a little sad for you.
I walk briskly 5 k every other day. Lift weights in between. I read of a
tye up between exercise and brain health. Am 83.5. Now taking B12 in
natural way. Mussels and or chicken liver pate.Go for it. METHYLCOBALAMIN
is B12.

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Profile picture for jbowens7 @jbowens7

I take a B12 injection once monthly. Is that enough? Also I eat sugar. I a pre-diabetic with a Hgb A1C of 5.9. Could the sugar be affecting my feet?

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@jbowens7 I am also pre-diabetic. The EMG test suggests my main leg nerves are damaged beyond repair. It is suggested that there is not cure. But a therapy program and exercises can help to keep my actual condition.

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Profile picture for KG @levelup

I found one that completely got rid of my peripheral neuropathy while on it, but I'm not advising anyone to try it. It was serendipitous. A friend of mine at work mentioned that he took lithium to help with his ADD/ADHD. He and I are very similar in our ways and I thought that I would give it a try. I did not have a prescription for his lithium medication type, and knowing that it's an element, searched Amazon.com to see if there was a supplement available. I found one called lithium orolate and the reviews were positive from it helping mood, anxiety, etc., so I thought I'd give it a try. I took the 5mg dosage and by the second day, my PN was gone. It had blocked it better than gabapentin and THC/CBD prescribed by my pain Dr. Now the side effects because there is no free lunch, right? I lost most of my sense of taste and had to urinate a lot more often. I stopped taking it and my PN is back and my sense of taste is slowly coming back. I didn't see any comments in the reviews about people losing their sense of taste and after an AI search believe that my system is hyper sensitive to lithium. Others in the comment section said they had been taking it for years with no side effects. Anyway, I'm not suggesting anyone take it, but I am here to say it helped my PN better than anything I've taken yet.

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How much gabepentin were you on before the supplement?

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Profile picture for mmenart84 @mmenart84

How much gabepentin were you on before the supplement?

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@ mmenart84 I was taking about 1200-1600mg

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New to group. Feel encouraged by the feedback.

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