Anyone have Aliya (PEF) treatment for lung cancer? How did it go?

Posted by kakalena @kakalena, Apr 18 2:04pm

I am scheduled to have the Aliya PEF (pulsed electricc field) image guided ablation on 4/23/26. It has just been approved for non small cell adenocarcinoma of the lungs. I am having it done in conjuction with a biopsy of lung nodules that have doubled in size in 4 months per CT sccan, and light up as probably cancerous from PET scan. I have been dealing with the lung cancer since January 2023 and pancreatic cancer since December 2024. I had the Whipple for the pancreas in December 2025. None of my cancers have been metastases. The biopsy won't have results for at least 7 days, but rather than putting me under twice, they ar going to do the Aliya at the same time. I am 78 years old. I have faith in my doctors, but since this such a new treatment, was wondering if anyone has had the Aliya, how successful it was, and were there any side effects.

Interested in more discussions like this? Go to the Lung Cancer Support Group.

Profile picture for kakalena @kakalena

@ladylennie
I had the Aliya on one nodule (there are several) at the same time as the biopsy, April 23, 2026. I'm 78 and they didn't want to put me under twice. The biopsy was inconclusive, atypical cells, possibly cancer. There had been an increase in size from November to March, from .9 cm to 1.8 cm. I had a CT scan on 5/15. There was some reduction in size, maybe 30%, but it was too early to say. The neighboring nodule, untreated, also had a similar reduction. CT was supposed to be 3 months later, but mis-communication between hospital where I get my imaging done, and pulmonologist. I travel to San Francisco for treatment, 130 miles away. The plan is to have another CT scan done in 3 months. I have experienced some shortness of breath, but am also on Immunotheraoy, Nivolmab, which I have been on for 3 years. I'm also 6 months post surgery for pancreatic cancer.
Bottom line, right now, I feel ok. I'm concerned about the breathing issue, but the procedure was done as an outpatient and was easy on me. Still checking and following up on shortness of breath issue. I hope that your procedure goes well. I will post what I learn if anything changess and post 3 mo. CT.

Jump to this post

@kakalena thank you. I'm now sitting at the hospital waiting to be called for the procedure. Will let you know results when I get them.

REPLY

The nodule was suspicious for malignancy so it was ablated. Full pathology next week. The procedure went well.

REPLY
Profile picture for ladylennie @ladylennie

The nodule was suspicious for malignancy so it was ablated. Full pathology next week. The procedure went well.

Jump to this post

@ladylennie
Excellent. Glad to hear it went well.

REPLY
Profile picture for kakalena @kakalena

@ladylennie
I had the Aliya on one nodule (there are several) at the same time as the biopsy, April 23, 2026. I'm 78 and they didn't want to put me under twice. The biopsy was inconclusive, atypical cells, possibly cancer. There had been an increase in size from November to March, from .9 cm to 1.8 cm. I had a CT scan on 5/15. There was some reduction in size, maybe 30%, but it was too early to say. The neighboring nodule, untreated, also had a similar reduction. CT was supposed to be 3 months later, but mis-communication between hospital where I get my imaging done, and pulmonologist. I travel to San Francisco for treatment, 130 miles away. The plan is to have another CT scan done in 3 months. I have experienced some shortness of breath, but am also on Immunotheraoy, Nivolmab, which I have been on for 3 years. I'm also 6 months post surgery for pancreatic cancer.
Bottom line, right now, I feel ok. I'm concerned about the breathing issue, but the procedure was done as an outpatient and was easy on me. Still checking and following up on shortness of breath issue. I hope that your procedure goes well. I will post what I learn if anything changess and post 3 mo. CT.

Jump to this post

@kakalena

I am curious as to what hospital in the San Francisco area did your PEF (Aliya) ablation. I am dealing with a second round of lung cancer and due to having the unpleasant side effect of a chronic broken rib from SBRT radiation the first round, I think the PEF ablation will be best for me. Part of my care team agrees (except the radiation oncologist, LOL!) I've refused radiation so far as I just can't fathom how I would deal with more lifelong radiation side effects. I have a lot of chronic pain from the broken rib and it's really limited lots of things I can do.

Thanks for sharing your experience with this new treatment. I'm so happy to hear of its success for you!

BPB

REPLY
Profile picture for bpb @bpb

@kakalena

I am curious as to what hospital in the San Francisco area did your PEF (Aliya) ablation. I am dealing with a second round of lung cancer and due to having the unpleasant side effect of a chronic broken rib from SBRT radiation the first round, I think the PEF ablation will be best for me. Part of my care team agrees (except the radiation oncologist, LOL!) I've refused radiation so far as I just can't fathom how I would deal with more lifelong radiation side effects. I have a lot of chronic pain from the broken rib and it's really limited lots of things I can do.

Thanks for sharing your experience with this new treatment. I'm so happy to hear of its success for you!

BPB

Jump to this post

@bpb
CPMC , California Pacific Medical Center. Dr. Heba Ismael. It was her first one but there were several other physicians present including one surgeon from UCFS ? who has done over 60. Dr. Ismael said she is doing 2 Aliyas a month now. I also had SBRT radiation for my pancreatic cancer at CPMC, Dr. Patricia Said. That worked very well for what was considered an inoperable tumor, but as a result of SBRT, I was able to have the Whipple surgery on pancreas.
The thing I liked about possible effects of Aliya is that the death of the treated nodule sends something out in your system that boosts your white blood cells' ability to fight same cancer in other locations. Here's hoping.

REPLY
Profile picture for kakalena @kakalena

@bpb
CPMC , California Pacific Medical Center. Dr. Heba Ismael. It was her first one but there were several other physicians present including one surgeon from UCFS ? who has done over 60. Dr. Ismael said she is doing 2 Aliyas a month now. I also had SBRT radiation for my pancreatic cancer at CPMC, Dr. Patricia Said. That worked very well for what was considered an inoperable tumor, but as a result of SBRT, I was able to have the Whipple surgery on pancreas.
The thing I liked about possible effects of Aliya is that the death of the treated nodule sends something out in your system that boosts your white blood cells' ability to fight same cancer in other locations. Here's hoping.

Jump to this post

@kakalena

Thanks for letting me know. I didn't realize that Sutter had a big hospital in SF. It is good to know that could be an option. I have an appointment with the interventional pulmonologist in early August (I've been waiting nearly a year to have this procedure) and if he has any reason to put it off, I'll check out Dr. Ismael. I had been thinking I might need to go to southern CA or Langone at NYU to get this done.

I'm guessing the reluctance to do it at my usual place of care may have to do with insurance or if PEF is now included in the Standard of
Care guidelines put out by the NCCN.

I am so appreciating your sharing because not a lot of people even know about this option and it is a struggle now with all the waiting.

Blessings!
BPB

REPLY
Please sign in or register to post a reply.