Lupron: Anyone have muscle weakness and severe leg pain?

I also have PC and have been on Lupron injections every 3 months for 15 months and have stiff legs and hips for about 3 months. I was doing OK until about almost 3 months ago. I then started feeling tired and started losing weight.

@maga

My legs and arm muscles began to painfully burn about 6 months after stopping Lupron. I also had severe headaches, brain fog, sweats, and enlargement of my heart. The muscle and head pains began to subside after 6 more months. My head hurt so bad that it was painful to even touch my skull. I am 83 years old and was stage 3 diagnosed in March 2025.

@edmond1971
I'm on every 3 months shots of Eligard for 2 years regimens my last shot is coming up in January and can't, Eligard is not a joke brain fog, dizziness when standing, lack of coordination, forgetting a lot and losing muscle mass depending on your age going to the gym helps a lot not easy just show up.

@bonjas

No warnings from doctors on these extremely painful and debilitating side effects. The manufacturers should be called to task. Household items come with safety precautions so why do these painful meds come with no precautions or suggestions. This should be illegal!

Unfortunately drugs company that's how they makes their money, oh I forgot to mention other side effects like hot flashes and night sweats.

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@bonjas

I also had the sweating 24 hours/day plus severe headaches.

@pesquallie exactly I nearly threw in the towel but my oncologist encourage me not to, she said January is just around the corner, get yourself a fan for the hot flashes its help a little.

Hi all - if at all possible ask for Orgovyx. Many members here had great results after switching to it from Lupron.

@pesquallie

I had no idea that I would lose my muscle mass and thus my mobility.

I stopped Lupron four years ago, and I still have not recovered my previous mobility.

I am 89. So age is probably the reason.

Wish you a fast recovery from the side effects,

@pesquallie For hot flashes at night, don't wear pajamas to bed. When the flash comes on, toss any covers and lay there spreadeagled under a ceiling fan. Expose your crotch, armpits, wrists, and ankles, all of which are important for cooling. And sweat is your friend, as long as you let it work to cool you under the breeze from the fan. If you don't have a ceiling fan in the bedroom, get one. That investment will pay off richly during your time on ADT.