Capecitabine side effects are really tough: What helps?

Posted by denise134 @denise134, Dec 20, 2024

Taking this drug finished 3rd cycle
1st 14 days was 3,900 mg day had severe mucositis with bleeding gums &scabs and bleeding nose sick stomach caused poor appetite but no nausea or vomiting - then 13th day diarrhea and blisters scabbing on chest so I quit 18 days not healed doc reduced dose 3,000 day

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I just finished my second cycle of Capecitabine earlier this week. For most of the second cycle I was fine physically until it came down to the last three days and then I felt awful physically and tired. I know part of the way I felt was due to vomiting almost on a daily basis. I am still a little weak but started to notice yesterday evening I was getting better. The Doctors have been trying to get my vomiting under control so we will see what happens going forward. I know I’ve lost almost 15 pounds in the past two weeks.

During the first cycle I felt much more fatigued after the first week on the medication. I was vomiting but not as much as I have recently the past couple weeks. During the second cycle I felt stronger over all and thought my body got used to the medication and then all of a sudden towards the end of the cycle I hit a brick wall. I currently don’t have much of an appetite however, prior to hitting the brick wall my appetite was fine but I just ate smaller portions.

I guess each cycle will I will feel different but I will enjoy the next week and a half of not having to take it.

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@tomrennie
Thank you! We're still waiting on the doc determining the dosage. My mom wants to just jump in and take but we're waiting for doc to decide what the actual RX is supposed to be. Sounds like too high can cause real problems. Any other stories where 90 year old had taken this med? If so at what dosage? I'm hoping it will be lower and longer but sounds like 2 weeks on a d 7 days off for 28-24 months. That seems intense for my mom.

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@pizmo Has the doctor mentioned DPD testing for your mother before recommending a dosage? I had this testing done and it showed that I was a intermediate metabolizer, meaning my body breaks down Xeloda at a slower rate. My doctor has me on a low dosage, 1000mg daily, 500mg in the morning, and 500mg in the evening. There are three categories of how well a body metabolizes Xeloda, normal, intermediate and poor. I would ask the doctor about this testing. Below is information about this testing.
DPD (dihydropyrimidine dehydrogenase) testing is a genetic test that checks for variants in the DPYD gene prior to starting Xeloda (capecitabine) chemotherapy. It is a critical safety measure, as individuals with DPD deficiency cannot efficiently break down the drug, which can lead to severe or fatal toxic side effects.

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