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New intel re Lithium Orotate
I have discussed previously that I have mild cognitive dysfunction and after two rounds of neuropsych testing over two years and Lab & imaging testing confirming my clinical profile, I am taking Lithium Orotate as a nutritional supplement. But I consume professional intel on studies religiously. Like this one.
https://www.psychiatrictimes.com/view/lecanemab-or-lithium-compare-benefits-risks-and-dose
The key question that stood out to me which the physician author (Dr Phelps) asks in his review of studies is below. I highly emcourage reading this. You have to follow some links and jump back and forth a bit but make the effort. For those of you fond of calculating elemental lithium there is a section on calculating equivalent dosing to the mice study.
“Brain lithium prevents amyloid plaque formation and phosphorylation of tau proteins. In the process of AD dementia, lithium is sequestered in plaques, creating a positive feedback loop: more plaque, less lithium, leading to more plaque, and so on. Giving lithium orotate to young adult mice almost completely prevented plaque formation and tau phosphorylation. Starting lithium orotate after plaques and phosphorylated tau have already formed almost completely reversed the expected cognitive impairment. Lithium carbonate is far less effective. If all this were true in humans, lithium orotate would be an obvious treatment both to prevent AD dementia and to treat it once detected.
Of course, skeptics’ first response has been “these are mouse data.” Aron et al point out that lithium levels in human and mouse brains are comparable, supporting the relevance of mouse models for studying the biological effects of lithium. Skeptics, including a prominent neurologist following a national presentation on AD treatment, have said that we should wait for a randomized trial of lithium orotate in humans (personal communication, August 2025). But the recent lithium carbonate randomized trial took 8 years to mount and complete. What shall we suggest to patients and families for the next 8 years?
A healthy lifestyle—including a Mediterranean-like diet, regular physical activity, and avoidance of smoking, excessive alcohol, social isolation, sleep disorders, and hearing loss—is an important means of preserving cognitive function in people at risk of developing dementia.
The subsequent article will compare lecanemab and lithium’s benefits, risks, and costs. With ApoE genotyping and the new pTau/amyloid blood test, patients and families need help now deciding between treatment alternatives.”
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@plus KAL at our Lazy Acres healthy grocer for
Got interrupted. 🙂
It was
You might enjoy reading about the glymphatic process in terms how the brain gets cleaned out at night. Google gives a decent overview. But fyi - it occurs during non-Rem, Stage 3 deep sleep.
@plus So apparently we're not to post prices? No worries. Guess I need to read the Connect guidelines. 🙂
@pb50 You might enjoy reading about the glymphatic ... during non-Rem, Stage 3 deep sleep
Thank you for that!! Looks quite interesting, and has me curious about if/how LiO could be involved in or interacting with that. Again, it's on those hapless rodents but promising.
Hopefully the focus on sleep will help, including any associated benefit from LiO. Speaking of which, I've just last night started splitting the now 10mg dose morning before breakfast and night before bed. Hoping that makes for better sleep and more stable blood LiO level.
It is such a precise fact I can't help but be inspired to know how much of my sleep is in Non-REM deep sleep. I have struggled to get one of the oura (sp?) rings but I may break down..
@plus I'm not sure - possibly. I just try to be cognizent those of us who get excited about learning new stuff and speak to it in a manner that might inspire followers. Goodness knows I am wandering through the Mild Cognitive Impairment darkness, groping my way. No one should be inspired by my choices - I just am inclined to get enthusiastic about them 🙂
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3 ReactionsFYI
Katie Couric did a very good 50 minute interview with Dr. Yankner that people might be interested in.
The Groundbreaking Alzheimer's Study You Need To Hear About
I can’t post a link, but In YouTube search for “ Couric yankner”.
One important thing that he says is that a reverse osmosis filter will remove the naturally occurring lithium carbonate in your drinking water.
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2 Reactions@nb14 awesome - thanks!!
Fyi - if it's useful, the RO filters are typically under the sink type. The Brita filters are not reverse osmosis.
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1 ReactionHello @nb14, I would like to add my welcome to Connect along with @pb50 and others. Since new members are not allowed to post links for a short period of time, I thought I would share the YouTube video for you.
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1 Reaction@johnbishop thanks !!
Good to hear from you.
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