Journavx (suzetrigine) new non-opioid medication for acute pain

Posted by julbpat @julbpat, Jun 18, 2025

I heard about this new medication (approved in January) here on Mayo Connect. In May, my PCP was willing to give me a one week prescription. None of my physicians - pain doctor, neurologist, primary care - were familiar with it. It is only approved for acute pain. As I explained to my really wonderful PCP, those of us with chronic pain can also have acute pain.
I was preparing for a beach vacation, my first travel in a year, and it involved hours of airport time. Then strolling on the beach.
I took the loading dose (100 mg) the night before. Guys, within an hour the burning in my feet had reduced by 80-90%. As I took the dose of 50 mg every 12 hours, my pain stayed at least 75% reduced. If I had a larger dose, or could take it more often, I swear I would hear angels singing.
I had zero side effects. It was a wonderful week. After my last dose, the pain came back full force.
The company has done trials for chronic pain with diabetic neuropathy patients, with poor results. I have idiopathic small fiber neuropathy. Journavx works on peripheral nerves.
When this medication is finally approved for chronic pain, many of us will finally get relief, with no awful side effects.
I did notify the company about my experience, and told them to put me first in line for the next trials. I’ve also shared this with all my doctors, including my hand surgeon. Hey, I’m having another hand surgery in a few months! Maybe I can get more then! Acute pain!

Interested in more discussions like this? Go to the Neuropathy Support Group.

Profile picture for julbpat @julbpat

@heisenberg34 I too have been told about ketamine infusions. My neurologist (in another city) was not actually endorsing it, just stating that he had some patients that got relief from it. I think here it was $4-500 per infusion. I stopped in the only clinic I could find that advertises ketamine infusions. It is owned by some local ER physicians. It was in a sketchy, rundown shopping center at a suboxone clinic. The receptionist was counting large sums of money behind the desk (cash only business). I looked around and said "'nope". Guess I wasn't desperate enough! But apparently it is a helpful treatment.

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@julbpat I hear you! $4500 per infusion would be onto stop me .. unless they could guarantee results. I would give them that to get rid of this pain.

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Profile picture for heisenberg34 @heisenberg34

@julbpat I hear you! $4500 per infusion would be onto stop me .. unless they could guarantee results. I would give them that to get rid of this pain.

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@heisenberg34 Sorry, $400-$500. Affordable!

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took Journavx 50 mg 2x day last week and results were very fast acting and amazing.
I'd had a cortisone shot in my toe 11 days before starting the Journavx and noted no improvement from that during that time...but with the new med started 12 days after the cortisone relief was close to immediate. Praise God. I had been unable to walk more than 50yards at a time without chronic pain from a very bad joint in my foot. Arthritis. No side effects from the new med. But sticker shock at the cost!
Pain free walking? Worth every penny. Will check with our insurance, Medicare A&B, our secondary Medicare supplement and our Wellcare Value Script Prescription Drug Plan about getting more coverage for the medication's long term pain relief. Will ask my Dr. if half the prescribed dose might be as effective. Good RX says all pharmacies are charging $143 for (10) 50mg pills - (with insurance)

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Profile picture for paulrohe @paulrohe

took Journavx 50 mg 2x day last week and results were very fast acting and amazing.
I'd had a cortisone shot in my toe 11 days before starting the Journavx and noted no improvement from that during that time...but with the new med started 12 days after the cortisone relief was close to immediate. Praise God. I had been unable to walk more than 50yards at a time without chronic pain from a very bad joint in my foot. Arthritis. No side effects from the new med. But sticker shock at the cost!
Pain free walking? Worth every penny. Will check with our insurance, Medicare A&B, our secondary Medicare supplement and our Wellcare Value Script Prescription Drug Plan about getting more coverage for the medication's long term pain relief. Will ask my Dr. if half the prescribed dose might be as effective. Good RX says all pharmacies are charging $143 for (10) 50mg pills - (with insurance)

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@paulrohe that’s great! I’m hearing of more patients getting prescriptions for chronic pain. I have been taking 50 mg twice a day for about 8 months. Yes, I paid over $900 several months. Then I paid just over $200 several times (I didn’t ask any questions!). Then somehow my doctors office got an authorization for Medicare to cover it. Since I hit the $2000 prescription cap, I’ve been paying $0! Not sure what will happen in January. I also haven’t tried to go without it. I still have neuropathy pain, it’s just a different intensity. Someday larger doses will be approved. My doctor, and apparently others, are getting on board with prescribing this for chronic pain.

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I tried Journavyx last last year. Did not help me. Glad to see that some are getting relief.

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Profile picture for heisenberg34 @heisenberg34

I am glad to hear that some of you have had some relief using Journavx. As I posted previously, I had no relief with this drug. Like many of you, I tried several, different iterations with no relief. I just came back from a different pain doctor here in Delaware. I was hoping to get some new treatment options. No such luck. She went over all the standard treatment options... injections, alations, surgeries, SCS, pain pump, etc. Check, check, and check. The only thing different that she mentioned was ketamine infusions, which is not covered by insurance. I would gladly pay out-of-pocket if it worked. Would like to know your experiences with ketamine and how much you paid, etc. I am pretty much resigned to spending the rest of my life with this chronic pain that has robbed me of the joy of my retirement. Thanking you all for your responses.

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@heisenberg34 have you put in a search for ketamine?
I read about people using this drug on FB in some neuropathy groups.
It is not legal in many states. It does work on the opioid centers of the brain I think. Some people do get relief.
Everyone finds their own way

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Profile picture for debbieod @debbieod

@heisenberg34 have you put in a search for ketamine?
I read about people using this drug on FB in some neuropathy groups.
It is not legal in many states. It does work on the opioid centers of the brain I think. Some people do get relief.
Everyone finds their own way

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@debbieod Another member mentioned ketamine to me. I have seen a few posts that mention it. I know that it can be lethal if administered in higher doses. I think Matthew Perry died from the drug overdose. I am always leery of a drug that has mixed reviews and is not covered by insurance(at least I don't believe so.
Anyhoo, thanks for the response. I will continue to monitor this drug.

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Ketamine is not used for chronic pain. It’s an effective acute pain reliever by injection but not infusion which is used for different reasons.

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