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HRT Intolerance or Side Effects?

Menopause | Last Active: 6 hours ago | Replies (37)

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@orion7962 can you tel me what is Pregnenalone?

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@tula17 Hi - So, Pregnenalone is apparently the "mother of all hormones" and helps the body produce hormones naturally, like building blocks. Im going to cut and paste from Google below. I've done a ton of reading about it, but not good at translating (lol) - if you use ChatGPT, that gives an excellent description. My understanding is that Pregnenalone can convert differently for different people since everyone is different, depending on what your body does with it, what you need, etc. I was on it a couple years ago in combination with many other things and I couldn't tell what was causing what side effects, so I stopped all. I re-started JUST Pregnenalone 3 weeks ago at a very low dose of 10mg. So far, its been extremely helpful. Here is a cut and paste from Google but definitely do more reading, and check with doctor before taking - my doctor found my Pregnenalone levels to be low. Hope this helps.

From Google: Pregnenolone is a naturally occurring neurosteroid and pro-hormone produced in the body from cholesterol. Often called the "mother of all hormones," it serves as the foundational building block for over 150 steroid hormones, including testosterone, estrogen, cortisol, and progesterone. As a supplement, pregnenolone is widely studied for its potential roles in brain function and hormone regulation.
How it Works & Potential Benefits Because it is a direct precursor to essential hormones, pregnenolone acts as a neurosteroid that supports the central nervous system.
Cognitive Function & Mood: It modulates neurotransmitter receptors (like GABA and NMDA), which has sparked research into its potential to improve working memory, focus, and negative symptoms associated with mood disorders.
Stress Response: Because it helps synthesize cortisol, it is sometimes used to support the body's adaptive response to emotional and physical stress.
Anti-Aging: Levels of pregnenolone naturally decline as we age. Some individuals take it to combat age-related fatigue or hormone declines, though definitive scientific evidence supporting these specific anti-aging benefits remains limited.